Michael J. Wise

Microevolution associated with clonal expansion of a hypervirulent, penicillin-resistant lineage of Neisseria meningitidis in Western Australia

August Mikucki, Eng Guan Chua, Chin Yen Tay, Michael J. Wise et autres

Neisseria meningitidis is a colonizer of the human nasopharynx which occasionally causes invasive meningococcal disease. Despite numerous reports of penicillin-resistant isolates, antimicrobial-resistant meningococcal clones have historically not persisted over long time periods or become globally distributed, presumably due to the imposed fitness …

au (code pays fourni par la source)

Can LLM Agents Maintain a Persona in Discourse?

Pranav Bhandari, Nicolas Fay, Michael J. Wise, Stephanie Meek et autres

Large Language Models (LLMs) are widely used as conversational agents, exploiting their capabilities in various sectors such as education, law, medicine, and more. However, LLMs are often subjected to context-shifting behaviour, resulting in a lack of consistent and interpretable personality-aligned interactions. Adherence …

Can LLM Agents Maintain a Persona in Discourse?

Pranav Bhandari, Nicolas Fay, Michael J. Wise, Stephanie Meek et autres

Large Language Models (LLMs) are widely used as conversational agents, exploiting their capabilities in various sectors such as education, law, medicine, and more.However, LLMs are often subjected to context-shifting behaviour, resulting in a lack of consistent and interpretable personality-aligned interactions.Adherence to psychological …

au, mn, de (code pays fourni par la source)

The Security Cooperation Toolkit and the Future of Great Power Competition

Michael J. Wise

Exploring the genetic architecture of ecophysiological traits in microbial ecology using statistical analysis of the properties of protein sequences: application to the glycogen accumulating organism (GAO) phenotype

Rohan B. H. Williams, Irina Bessarab, Michael J. Wise, Krithika Arumugam

Abstract Nearly 50 years ago, King and Wilson introduced a key distinction between two types of genetic variation–named structural and regulatory variation–for exploring the molecular basis for phenotypic traits. Structural variation is genetic variation that will influence gene product structure via changes …

sg, au (code pays fourni par la source)

Slice Transformer and Self-supervised Learning for 6DoF Localization in 3D Point Cloud Maps

Muhammad Ibrahim, Naveed Akhtar, Saeed Anwar, Michael J. Wise et autres

Precise localization is critical for autonomous vehicles. We present a self-supervised learning method that employs transformers for the first time for the task of outdoor localization using LiDAR data. We propose a pre-text task that reorganizes the slices of a 360° LiDAR …

au, sa (code pays fourni par la source)

Travel-associated lineages and unique endemic antimicrobial-susceptible lineages of Neisseria gonorrhoeae predominate in Western Australia

Barakat A. Al Suwayyid, Ethan C. Haese, Shakeel Mowlaboccus, Julie Pearson et autres

In Australia, gonococcal isolates are monitored for antimicrobial susceptibilities. In Western Australia (WA), gonorrhoea notification rates increased by 63 % between 2013 and 2016, with the steepest increase occurring between 2015 and 2016, before stabilizing at this higher baseline between 2017 and …

au, sa (code pays fourni par la source)

Slice Transformer and Self-supervised Learning for 6DoF Localization in 3D Point Cloud Maps

Muhammad Ibrahim, Naveed Akhtar, Saeed Anwar, Michael J. Wise et autres

Precise localization is critical for autonomous vehicles. We present a self-supervised learning method that employs Transformers for the first time for the task of outdoor localization using LiDAR data. We propose a pre-text task that reorganizes the slices of a $360^\circ$ LiDAR …

Editorial: What does not kill you makes you stronger: Interactions between environmental stresses and microbial virulence

Liang Wang, Lingjun Zhan, Michael J. Wise

The intriguing sit-and-wait hypothesis predicts that "virulence should be positively correlated with durability in the external environment because high durability reduces the dependence of transmission on host mobility" (Walther and Ewald, 2004) (Figure 1). Since the hypothesis was first proposed in the …

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Ten simple rules for investigating (meta)genomic data from environmental ecosystems

Paton Vuong, Michael J. Wise, Andrew S. Whiteley, Parwinder Kaur

Metagenomics is the sequencing and study of DNA directly from environmental samples and is an approach used in microbial ecology to explore the diversity and functions of microbial communities [1].The study of the metagenome presents an avenue to investigate environmental microorganisms in-situ …

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Deep learning models for RNA secondary structure prediction (probably) do not generalize across families

Marcell Szikszai, Michael J. Wise, Amitava Datta, Max Ward et autres

MOTIVATION: The secondary structure of RNA is of importance to its function. Over the last few years, several papers attempted to use machine learning to improve de novo RNA secondary structure prediction. Many of these papers report impressive results for intra-family predictions …

au, us (code pays fourni par la source)

From rags to enriched: metagenomic insights into ammonia‐oxidizing archaea following ammonia enrichment of a denuded oligotrophic soil ecosystem

Paton Vuong, Benjamin Moreira‐Grez, Michael J. Wise, Andrew S. Whiteley et autres

Stored topsoil acts as a microbial inoculant for ecological restoration of land after disturbance, but the altered circumstances frequently create unfavourable conditions for microbial survival. Nitrogen cycling is a critical indicator for ecological success and this study aimed to investigate the cornerstone …

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