August Mikucki

Longitudinal surveillance of group A streptococcal pharyngitis and impetigo in remote Western Australian school children informs acute rheumatic fever prevention

Janessa Pickering, Dylan D Barth, Bernadette Z.Y. Wong, E. McKinnon et autres

The prevalence of impetigo and pharyngitis - which are both superficial group A streptococcus (GAS) infections that precede acute rheumatic fever - is poorly defined. Guidelines recommend the early diagnosis of both infections to prevent ARF; however, screening to enable the concurrent …

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Microevolution associated with clonal expansion of a hypervirulent, penicillin-resistant lineage of Neisseria meningitidis in Western Australia

August Mikucki, Eng Guan Chua, Chin Yen Tay, Michael J. Wise et autres

Neisseria meningitidis is a colonizer of the human nasopharynx which occasionally causes invasive meningococcal disease. Despite numerous reports of penicillin-resistant isolates, antimicrobial-resistant meningococcal clones have historically not persisted over long time periods or become globally distributed, presumably due to the imposed fitness …

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Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis

August Mikucki, Charlene M. Kahler

is commensal of the human pharynx and occasionally invades the host, causing the life-threatening illness invasive meningococcal disease. The meningococcus is a highly diverse and adaptable organism thanks to natural competence, a propensity for recombination, and a highly repetitive genome. These mechanisms …

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21: CLOSED GENOME AND METHYLOME OF TWO ISOLATES OF NEISSERIA MENINGITIDIS FROM CLONAL COMPLEXES 8 AND 11

August Mikucki, Eng Chua, Chin Yen Tay, Shakeel Mowlaboccus et autres

The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis

August Mikucki, Nicolie R. McCluskey, Charlene M. Kahler

Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the human nasopharynx. It shares and competes for this niche with a number of other Neisseria species including N. lactamica, N. cinerea and N. mucosa . Unlike these other members of …

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Modelling evolutionary pathways for commensalism and hypervirulence in Neisseria meningitidis

August Mikucki, Michael J. Wise, Charlene M. Kahler

is an opportunistic pathogen, with some clonal complexes, such as cc53, effectively acting as commensal colonizers, while other genetic lineages, such as cc11, are rarely colonizers but are over-represented in IMD and are termed hypervirulent. This study examined theoretical evolutionary pathways for …

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