Pascal Ferré

Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway

Cécile L. Bandet, Sophie Tan, Sarah Ali-Berrada, Mélanie Campana et autres

Ceramides have been shown to play a major role in the onset of skeletal muscle insulin resistance and therefore in the prevalence of type 2 diabetes. However, many of the studies involved in the discovery of deleterious ceramide actions used a nonphysiological, …

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Métabolisme : la renaissance !

Pascal Ferré

International audience

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SREBP-1c and lipogenesis in the liver: an update

Pascal Ferré, Franck Phan, Fabienne Foufelle

Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the synthesis of lipids from glucose in the liver, a process which is of utmost importance for the storage of energy. Discovered in the early nineties by B. Spiegelman and by …

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Roles of Ceramides in Non-Alcoholic Fatty Liver Disease

Éric Hajduch, Floriane Lachkar, Pascal Ferré, Fabienne Foufelle

Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the …

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Dihydroceramides in Triglyceride-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Disease Severity in Type 2 Diabetes

Aurélie Carlier, Franck Phan, Anaïs Szpigel, Éric Hajduch et autres

Plasma dihydroceramides are predictors of type 2 diabetes and related to metabolic dysfunctions, but the underlying mechanisms are not characterized. We compare the relationships between plasma dihydroceramides and biochemical and hepatic parameters in two cohorts of diabetic patients. Hepatic steatosis, steatohepatitis, and …

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Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases

Floriane Lachkar, Pascal Ferré, Fabienne Foufelle, Alexandra Papaioannou

Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded as biologically inactive. They are metabolic intermediates of the de novo sphingolipid synthesis pathway, and are converted into ceramides (Cers) with the addition of a double bond. Ceramides …

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Fuel Metabolism in the Fetus

Alain Ktorza, Pascal Ferré

In mammalians, fetal life is characterized by intense growth and development. These processes require abundant nutrients and fuels which are exclusively supplied by the mother via a key-organ of feto-matemal exchanges—the placenta. The transfer of metabolic substrates to the fetus depends on …

Fuel Metabolism in the Fetus

Alain Ktorza, Pascal Ferré

Massive lactic acidosis and ketoacidosis with glucagon deficiency in a chronic alcoholic patient

Philippe Boudou, Michel Djibré, Fawzia Ibrahim, Soraya Fellahi et autres

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Stress du réticulum endoplasmique et stéatopathies métaboliques

Floriane Lachkar, Alexandra Papaioannou, Pascal Ferré, Fabienne Foufelle

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent pathology associated with obesity. It encompasses a spectrum of hepatic disorders ranging from steatosis to non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis and hepatocellular carcinoma (HCC). Endoplasmic reticulum (ER) stress has been …

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Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

Cécile L. Bandet, Rana Mahfouz, Julien Véret, Athanassia Sotiropoulos et autres

One main mechanism of insulin resistance (IR), a key feature of type 2 diabetes, is the accumulation of saturated fatty acids (FAs) in the muscles of obese patients with type 2 diabetes. Understanding the mechanism that underlies lipid-induced IR is an important …

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BCAA and ER stress activate SREBP-1c cleavage and hepatic lipogenesis through mTOR

Franck Phan, Mélissa Flamment, Mei Hu, Isabelle Hainault et autres