Jacob J. Greene

Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis

Ainhoa Etxeberría, Yun‐An Shen, Stephen Vito, Sean M. Silverman et autres

Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist antibodies in multiple mixed-sex mouse models of Alzheimer's disease (AD) pathology and …

us, fr, sg, nz, ca (code pays fourni par la source)

ATF3 is a neuron‐specific biomarker for spinal cord injury and ischaemic stroke

Jonathan Z. Pan, Zhanqiang Wang, Wei Sun, Peipei Pan et autres

BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology …

us, cn (code pays fourni par la source)

Clinical Outcomes of Erector Spinae Plane Block for Midline Sternotomy in Cardiac Surgery: A Systematic Review and Meta‐Analysis

Jacob J. Greene, Sharon Chao, Ban C. H. Tsui

us (code pays fourni par la source)

BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep

Daniela Rojo, Louisa Dal Cengio, Anna Badner, Samuel Kim et autres

Myelination depends on the maintenance of oligodendrocytes that arise from oligodendrocyte precursor cells (OPCs). We show that OPC-specific proliferation, morphology, and BMAL1 are time-of-day dependent. Knockout of Bmal1 in mouse OPCs during development disrupts the expression of genes associated with circadian rhythms, …

us, fi (code pays fourni par la source)

TREM2 ‐dependent microglial function is essential for remyelination and subsequent neuroprotection

Yuanyuan Wang, Roxanne V. Kyauk, Yun‐An Shen, Luke Xie et autres

Disability in multiple sclerosis (MS) is driven in part by the failure of remyelination and progressive neurodegeneration. Microglia, and specifically triggering receptor expressed on myeloid cells 2 (TREM2), a factor highly expressed in microglia, have been shown to play an important role …

us, fr (code pays fourni par la source)

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep

Daniela Rojo, Anna Badner, Louisa Dal Cengio, Samuel Kim et autres

Abstract Myelination depends on maintenance of oligodendrocytes that arise from oligodendrocyte precursor cells (OPCs). We show that the dynamic nature of oligodendroglia and myelination are regulated by the circadian transcription factor BMAL1. Bmal1 knockdown in OPCs during development – but not adulthood …

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Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

Anna C. Geraghty, Erin M. Gibson, Reem Ghanem, Jacob J. Greene et autres

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Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

Erin M. Gibson, Surya Nagaraja, Alfonso Ocampo, Lydia Tam et autres

us (code pays fourni par la source)