Bróna M. Moloney

β-Blockers in Hemodialysis

Bróna M. Moloney, Finnian R. Mc Causland

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Dapagliflozin: A Role for Heart Failure Treatment in Dialysis?

Bróna M. Moloney, Finnian R. Mc Causland

Cardiovascular (CV) disease is the leading cause of death among patients with kidney failure requiring hemodialysis (HD), occurring in approximately 40-50% of this population. Around 40% of prevalent patients have a diagnosis of heart failure (HF), while approximately 25% of patients develop …

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Heart Rate Variability and Inflammatory Biomarkers in Patients with CKD

Bróna M. Moloney, Simon Correa, Glenn Matthew Chertow, Finnian R. Mc Causland

Background: Dysutonomia is common among patients with advanced CKD and is associated with death and cardiovascular (CV) events. Perturbations in sympathovagal balance are hypothesized to contribute to a pro-inflammatory milieu; it is also plausible that inflammation could promote dysautonomia. We explored the …

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Association of the Fibrosis-4 Score with the Risk of Cardiovascular Disease and Death in Patients with CKD: Insights from the CRIC Study

Simon Correa, Bróna M. Moloney, Valentina A Castro Loaiza, Tomás Correa Gaviria et autres

Background: The Fibrosis-4 (FIB-4) score is used to estimate the risk of liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). A higher FIB-4 score is associated with major adverse cardiovascular (CV) events in patients with MASLD, patients with pre-existing …

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Association of Diabetes with Heart Rate Variability during Hemodialysis

Bróna M. Moloney, Glenn Matthew Chertow, Finnian R. Mc Causland

Key Points Patients with diabetes on hemodialysis had 18% lower SD of the normal-to-normal R-R interval, a proxy for lower heart rate variability. The association of diabetes with intradialytic hypotension was not mediated by SD of the normal-to-normal R-R interval. Targeted therapies …

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The impact of a secondary, rare, non-pathogenic PKD1 variant on disease progression in autosomal dominant polycystic kidney disease

Elhussein A. E. Elhassan, Kane E. Collins, Sophia Heneghan, Edmund H. Gilbert et autres

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is caused primarily by pathogenic variants in the PKD1 and PKD2 genes. Although the type of ADPKD variant can influence disease severity, rare, hypomorphic PKD1 variants have also been reported to modify disease severity or …

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Rule‐based clinician‐developed programmes can facilitate haemodialysis clinical workflows

Shrirajh Satheakeerthy, Andrew E. C. Booth, Weng Onn Chan, Bróna M. Moloney et autres

There are routine hospital workflows that are not addressed by certain institutional electronic medical records, including the detection of patients requiring haemodialysis who are admitted under non-nephrology services. In this study, the feasibility and performance of a clinician-developed automated haemodialysis patient finder …

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Association of Diabetes with Heart Rate Variability in Hemodialysis

Bróna M. Moloney, Glenn Matthew Chertow, Finnian R. Mc Causland

Background: Autonomic dysfunction is common among patients with diabetes mellitus (DM) receiving hemodialysis (HD) and may contribute to a higher risk of intra-dialytic hypotension. We explored the association of DM with heart rate variability (HRV; a surrogate of dysautonomia) and explored if …

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Association of Diabetes with Changes in Blood Pressure during Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial

Bróna M. Moloney, Glenn Matthew Chertow, Finnian R. Mc Causland

INTRODUCTION: Diabetes mellitus is a common cause of kidney failure and is often complicated by autonomic neuropathy, which may have implications for blood pressure (BP) homeostasis during hemodialysis (HD). METHODS: In this post hoc analysis of the Frequent Hemodialysis Network (FHN) Daily …

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The association between ambient UVB dose and ANCA-associated vasculitis relapse and onset

Jennifer M. Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White et autres

BACKGROUND: The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differences between granulomatous and non-granulomatous AAV phenotypes. A narrow ultraviolet B spectrum induces vitD synthesis …

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Comparison of catheters or new arteriovenous fistulas for commencement of haemodialysis in pregnant women with chronic kidney disease: an international observational study

Shilpanjali Jesudason, Erandi Hewawasam, Bróna M. Moloney, Rachel Yi Ping Tan et autres

BACKGROUND: Evidence surrounding vascular access options for commencing dialysis in pregnancy complicated by chronic kidney disease (CKD) is limited. Creation of new arteriovenous fistulas (AVFs) in pregnant women is rare. METHODS: Retrospective cohort study of approaches to vascular access in pregnancy in …

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A cohort study to investigate sex-specific differences in ANCA-associated glomerulonephritis outcomes

Jennifer M. Scott, Carolina Canepa, Antonia Buettner, LOUISE M. RYAN et autres

Data surrounding sex-specific differences in ANCA-associated vasculitis glomerulonephritis (ANCA-GN) outcomes is sparse. We hypothesised that the previously observed increased risk of end-stage kidney disease (ESKD) in males is driven by sex-specific variation in immunosuppression dosing. Patients were recruited to the Irish Rare …

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