Accès ouvert
2026
article
OpenAlex
Ricardo A. Leitão, José Luís Alves, Ana L Bernardo, Anabela Mota‐Pinto et autres
Traumatic brain injury (TBI) initiates a complex cascade of secondary injury mechanisms, including neurovascular dysfunction, neuroinflammation, and glial activation, which progressively contribute to long-term neurological deficits. Although the primary mechanical insult is typically unilateral, secondary pathological processes can extend beyond the impact …
pt
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Accès ouvert
2025
article
OpenAlex
Ana Paula Silva, Sofia Viana, Inês R. Pita, Cristina Lemos et autres
Background: Gastrointestinal (GI) disturbances occur frequently in the early premotor stage of Parkinson’s disease (PD). These GI impairments are associated, at least in part, with dopaminergic dysfunction in the myenteric plexus. However, the enteric nervous system (ENS) pathophysiology underlying GI dysfunction in …
pt, at, br
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Accès ouvert
2025
article
OpenAlex
Eliane S. Sanches, Ricardo A. Leitão, Filipa I. Baptista, Sandra Isabel Mota et autres
Methylphenidate (MPH) is widely used as the first-line pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD). However, its misuse as a cognitive enhancer has been increasing worldwide. Despite the scientific advances in understanding the effects of MPH on the brain, its impact on the …
pt
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Accès ouvert
2025
article
OpenAlex
Daniela M. Simões, José Carreira, Alexandre Annes Henriques, Rita Gaspar et autres
Stress is a contributing factor for several mood disorders, including depression and anxiety which are associated with significant changes in behavioural and cellular domains. Additionally, sex differences in the prevalence of these neuropsychiatric disorders are well established. Emerging evidence suggests that stress …
pt
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2025
article
OpenAlex
Cidimar Andreatta, Ivan Meloti Capucho, Salatiel Dos Santos Ribeiro, Ana Cláudia Correira da Silva Carminati et autres
O presente artigo apresenta um mapeamento de pesquisas envolvendo o uso do Scratch em processos de ensino e aprendizagem, tanto na Educação Básica quanto no Ensino Superior, no período de 2019 a 2025, totalizando 42 trabalhos. O presente estudo de mapeamento teve …
br
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2025
article
OpenAlex
Ana Paula Silva, Rafael Martins Mendes, Guilherme Mendonça Rodrigues, Fábio Augusto do Amaral
O presente artigo teve como objetivo o planejamento, a construção e a aplicação de um jogo educativo interdisciplinar, envolvendo conceitos matemáticos e educação ambiental, abordando os conteúdos de potenciação, radiciação associados à temática de educação ambiental. O grupo de aplicação dos jogos …
br
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Accès ouvert
2024
article
OpenAlex
Ana Paula Silva, Raimundo dos Santos Marcolino, Jorge Soares Menor Filho, Danilo Lima Falcão et autres
Este estudo investiga a probabilidade de lesões em jogadores de futebol profissional, considerando variáveis como idade, posição, histórico de lesões e intensidade do treinamento. Utilizando a regressão de Poisson para modelagem estatística, os dados foram coletados de sites oficiais da Confederação Brasileira …
br
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2024
article
OpenAlex
Ana Paula Silva, Thayse Nayara Freitas do Vale Santanna, Christian Marques Couto, Roberta Corrêa Macedo et autres
Abstract Background To improve the diagnostic accuracy of the state of consciousness of patients with severe brain injury, Giacino et al. introduced the Coma Recovery Scale (CRS) in 1991, which underwent revision in 2004, resulting in the revised CRS scale (CRS-R). Objective …
br
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2024
article
OpenAlex
João R Corrêa, Ana Paula Silva, Joana Dias Coelho, Renato Gonçalves et autres
Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune demyelinating disorder of the central nervous system that can mimic other neurological diseases, such as multiple sclerosis. ADEM is thought to manifest in the presence of environmental triggers, namely viral or bacterial infections, with …
pt
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Accès ouvert
2024
article
OpenAlex
João R Corrêa, Ana Paula Silva, Maria Pacheco, Dalia Estevão
Primary pyomyositis, also known as tropical pyomyositis, is a primary bacterial infection of skeletal muscle following hematogenous infections. It is primarily caused by Staphylococcus aureus or Group A Streptococcus and predominantly affects children and young adults. Although rarely observed in temperate climates, …
pt
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Accès ouvert
2024
article
OpenAlex
Eliane S. Sanches, Daniela M. Simões, Filipa I. Baptista, Ana Paula Silva
BACKGROUND: Neurovascular interfaces, specifically the blood-brain barrier (BBB) and blood-retinal barrier (BRB), play pivotal roles in maintaining the homeostasis of the central nervous system (CNS). For a long time, these structures were seen only as a way of protection, but we currently …
pt
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Accès ouvert
2024
article
OpenAlex
Liliana Santos, Francesca Tomatis, Hugo R. S. Ferreira, Sara F.F. Almeida et autres
BACKGROUND: Brain metastasis (BrM) is a devastating end-stage neurological complication that occurs in up to 50% of human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients. Understanding how disseminating tumor cells manage to cross the blood-brain barrier (BBB) is essential …
pt
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