Kevin M. Prise

Impact of ataxia-telangiectasia mutated (ATM) loss on radiobiological and immune response to radium-223 in prostate cancer in vitro models.

Victoria L. Dunne, Timothy Wright, Aislinn Toner, Melissa LaBonte Wilson et autres

INTRODUCTION: Personalised medicine approaches are redefining the therapeutic landscape for men with metastatic castration-resistant prostate cancer (mCRPC). While poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated clinical benefit in patients with BRCA1/2 mutant tumours, the therapeutic efficacy of these inhibitors in Ataxia-telangiectasia mutated (ATM)-mutated …

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Impact of ataxia-telangiectasia mutated (ATM) loss on radiobiological and immune response to radium-223 in prostate cancer in vitro models

Victoria L. Dunne, Timothy Wright, Kienan I. Savage, John A. Sullivan et autres

IntroductionPersonalised medicine approaches are redefining the therapeutic landscape for men with metastatic castration-resistant prostate cancer (mCRPC). While poly(ADP-ribose) polymerase (PARP) inhibitors have demonstrated clinical benefit in patients with BRCA1/2 mutant tumours, the therapeutic efficacy of these inhibitors in Ataxia-telangiectasia mutated (ATM)-mutated prostate …

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Refining photon- and particle-induced chromosome aberration predictions for simplified and detailed radiation damage models

Shannon J Thompson, Kevin M. Prise, Stephen J McMahon

Abstract Objective. Besides preferential tumour targeting, particle therapy has an increased relative biological effectiveness compared to x-rays, but uncertainties in this effectiveness prevent full exploitation of its clinical benefits. Mechanistic radiation response models can predict the effects of different radiation qualities but …

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Investigation of image-guided in vivo irradiation on voiding patterns and bladder contractility in female mice

Sarah E. McDowell, Conor J. Breen, Niamh McKerr, Kirtiman Srivastava et autres

Radiotherapy for pelvic malignancies impacts the bladder causing urinary symptoms in many patients. Preclinical models using image-guided irradiation enable investigation of the physiology underlying radiation-response in the bladder. We aimed to characterise voiding patterns and bladder contractility following image-guided irradiation of the …

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Dose, dose rate and split dose impacts murine skin responses following photon FLASH irradiation

Kathryn H. Brown, Mihaela Ghita, Malachy P McIvor, Mark P McDowell et autres

INTRODUCTION: Preclinical evidence has demonstrated the potential of FLASH radiotherapy (FLASH-RT) to spare normal tissues compared to conventional (CONV) exposures. Most FLASH studies have used ultra-high dose rate (>40 Gy/sec) electrons and protons whilst comparatively few studies have reported photon FLASH responses. …

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From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI)

Katalin Hidéghety, G.A.P. Cirrone, Katia Parodi, Kevin M. Prise et autres

Abstract The extreme light infrastructure (ELI) is emerging as a state-of-the-art facility providing international users with open access to ultrashort laser-driven particle bunches, ranging from a few femtoseconds to a few nanoseconds, for advanced radiobiology studies. ELI offers femtosecond-class laser pulses and …

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Single-pulse Gy-scale irradiation of biological cells at 1013 Gy s−1 average dose-rates from a laser-wakefield accelerator

C. A. McAnespie, Pankaj Chaudhary, M. J. V. Streeter, Stanley W. Botchway et autres

Abstract Objective. We report on the first experimental characterisation of a laser-wakefield accelerator able to deliver, in a single pulse, doses in excess of 1 Gy on timescales of the order of a hundred femtoseconds, reaching unprecedented average dose-rates of up to …

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A new user platform for radiobiological research with laser-driven protons at ELI Beamlines: first experiments

Pavel Bláha, Pankaj Chaudhary, M. Borghesi, G.A.P. Cirrone et autres

Due to the growing number of cancer patients, advancements in accelerator technologies, such as the laser-driven accelerators that are being explored at the ELI Beamlines facility, are essential. During the first biological experiments with multi-shot laser-driven proton beams (LDP), human skin fibroblasts …

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Time-lapse imaging of cells in spatially fractionated X-ray fields using a mini beam as an alternative to accelerator-based sub-millimeter beams

Kiichi Kaminaga, Hisanori Fukunaga, Eri Hirose, Ritsuko Watanabe et autres

Due to the limited number of accelerator-based X-ray facilities worldwide that provide beams with an adjustable size, their application for radiobiological research purposes has been restricted. Thus, the development of alternative methods is of technical importance for investigating cell/tissue responses in spatially …

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4594 The association between dose and location of the dominant intraprostatic lesion with outcomes in patients treated with LDR prostate brachytherapy

Orla Anne Houlihan, Sergio Esteve, Geraldine Workman, Monica M. Byrne et autres

ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons

Pavel Bláha, Kevin M. Prise, M. Borghesi, Francesco Paolo Cammarata et autres

The ELIMAIA-ELIMED beamline, powered by the L3 HAPLS petawatt laser, enables the irradiation of biological samples with intermediate-energy laser-driven protons (LDP) in a multi-shot regime. In the pilot radiobiological experiment, protons with a mean energy of ∼24 MeV and doses up to …

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The importance of standardization and challenges of dosimetry in conventional preclinical radiation biology research

Mark A. Hill, Ileana Silvestre Patallo, Adam H. Aitkenhead, Magdalena Bazalova‐Carter et autres

To fully exploit the prospects presented by the increasing focus on biological approaches for enhancing radiotherapy outcomes, improvements in repeatability and translatability of radiobiological and preclinical studies are required. This requires the development and adoption of appropriate dosimetric standards and reproducible approaches …

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