David L. Dünner

Continuation Treatment of Chronic Depression: A Comparison of Nefazodone, Cognitive Behavioral Analysis System of Psychotherapy, and Their Combination

James H. Kocsis, Augustus John Rush, A. John Rush, John C. Markowitz et autres

Little is known about the relative benefits of psychotherapy, medication, and combined treatment as continuation therapies for chronic forms of major depressive disorder (MDD) after a positive response to acute treatment. We hypothesize that combined treatment would demonstrate superior continuation phase outcomes …

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Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder

Scott T. Aaronson, Charles R. Conway, Charles M. Gordon, Ying-Chieh Lee et autres

Vagus nerve stimulation (VNS) therapy is a long-term intervention for treatment-resistant major depression (TRD) adjunctive to treatment as usual (TAU). To enhance clinical decision- making, we identified subgroups that respond especially well or poorly with active VNS vs no stimulation sham VNS …

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Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial

Charles R. Conway, Scott T. Aaronson, Harold A. Sackeïm, Mark S. George et autres

BACKGROUND: Few treatments are available for individuals with marked treatment-resistant depression (TRD). OBJECTIVE: Evaluate the safety and effectiveness of FDA-approved adjunctive vagus nerve stimulation (VNS) in patients with marked TRD. METHODS: This 12-month, multicenter, double-blind, sham-controlled trial included 493 adults with marked …

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Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial

A. John Rush, Charles R. Conway, Scott T. Aaronson, Mark S. George et autres

BACKGROUND: Depression treatments aim to minimize symptom burden and optimize quality of life (QoL) and psychosocial function. OBJECTIVE: Compare the effects of adjunctive versus sham vagus nerve stimulation (VNS) on QoL and function in markedly treatment-resistant depression (TRD). METHODS: In this multicenter, …

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Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report

Charles R. Conway, Scott T. Aaronson, Harold A. Sackeïm, Walter J. Duffy et autres

BACKGROUND: RECOVER is a randomized sham-controlled trial of vagus nerve stimulation and the largest such trial conducted with a psychiatric neuromodulation intervention. OBJECTIVE: To describe pre-implantation baseline clinical characteristics and treatment history of patients with unipolar, major depressive disorder (MDD), overall and …

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Bipolar Disorder Differential Diagnosis Screening Measure

Gordon Barraclough Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda et autres

A new machine learning-derived screening measure for differentiating bipolar from unipolar mood disorders

Gordon Barraclough Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda et autres

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Categorical differentiation of the unipolar and bipolar disorders

Gordon Barraclough Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda et autres

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Differentiating mania/hypomania from happiness using a machine learning analytic approach.

Gordon Barraclough Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda et autres

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Bipolar II Disorder: Recognition, Understanding, and Treatment

David L. Dünner

Dr Dunner is the Director of the Center for Anxiety and Depression, Mercer Island, WA, and Professor Emeritus, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA Marcia L. Verduin, MD, Book Editor Overall rating: 5 stars

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The bipolar disorders: A case for their categorically distinct status based on symptom profiles

Gordon Barraclough Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda et autres

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Refined diagnostic criteria for the bipolar disorders: phase two of the AREDOC project

Gordon Barraclough Parker, Gabriela Tavella, Tahlia Ricciardi, Martin Alda et autres

OBJECTIVE: As limitations exist across DSM criteria sets for defining and differentiating the bipolar disorders generally and their component bipolar I (BP-1) and bipolar II (BP-II) sub-types, we sought to generate empirically based criteria. METHOD: We formed an international Task Force (TF) …

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