Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report
Rattachement africain : us, gb, sg. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: RECOVER is a randomized sham-controlled trial of vagus nerve stimulation and the largest such trial conducted with a psychiatric neuromodulation intervention. OBJECTIVE: To describe pre-implantation baseline clinical characteristics and treatment history of patients with unipolar, major depressive disorder (MDD), overall and as a function of exposure to interventional psychiatric treatments (INTs), including electroconvulsive therapy, transcranial magnetic stimulation, and esketamine. METHODS: Medical, psychiatric, and treatment records were reviewed by study investigators and an independent Study Eligibility Committee prior to study qualification. Clinical characteristics and treatment history (using Antidepressant Treatment History [Short] Form) were compared in those qualified (N = 493) versus not qualified (N = 228) for RECOVER, and among the qualified group as a function of exposure to INTs during the current major depressive episode (MDE). RESULTS: Unipolar MDD patients who qualified for RECOVER had marked TRD (median of 11.0 lifetime failed antidepressant treatments), severe disability (median WHODAS score of 50.0), and high rate of baseline suicidality (77% suicidal ideation, 40% previous suicide attempts). Overall, 71% had received at least one INT. Compared to the no INT group, INT recipients were younger and more severely depressed (QIDS-C, QIDS-SR), had greater suicidal ideation, earlier diagnosis of MDD, and failed more antidepressant medication trials. CONCLUSIONS: RECOVER-qualified unipolar patients had marked TRD and marked treatment resistance with most failing one or more prior INTs. Treatment with ≥1 INTs in the current MDE was associated with earlier age of MDD onset, more severe clinical presentation, and greater treatment resistance relative to patients without a history of INT. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT03887715.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report
- Date Crossref
- 01/03/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Washington University in St. Louis Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
-
University of Missouri–St. Louis pays non établi dans la noticeUniversité ou école supérieure
-
Sheppard Pratt Health System pays non établi dans la noticeÉtablissement de santé
-
Columbia University Departments of Psychiatry and Radiology pays non établi dans la noticeUniversité ou école supérieure
-
Alivation (United States) pays non établi dans la noticeEntreprise
-
Stedman Clinical Trials pays non établi dans la noticeStructure de recherche
-
The University of Texas Health Science Center at Houston McGovern Medical School pays non établi dans la noticeUniversité ou école supérieure
-
Emory University Department of Psychiatry and Behavioral Sciences pays non établi dans la noticeUniversité ou école supérieure
-
University of California ATP Clinical Research pays non établi dans la noticeUniversité ou école supérieure
-
Hoag Memorial Hospital Presbyterian pays non établi dans la noticeÉtablissement de santé
-
Center for Anxiety and Depression pays non établi dans la noticeÉtablissement de santé
-
Florida Center for Dermatology pays non établi dans la noticeÉtablissement de santé
Department of Psychiatry — Washington University in St. Louis, University of Missouri–St. Louis et Sheppard Pratt Health System, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.