Lucas Caldi Gomes

Proteomic Profiling of Cerebrospinal Fluid Identifies Immune and Synapto-Axonal ALS Subtypes

Laura Tzeplaeff, X. Liu, Clara Meijs, Lucas Caldi Gomes et autres

de, us, au, fr (code pays fourni par la source)

Identification and validation of a tear fluid-derived protein biomarker signature in patients with amyotrophic lateral sclerosis

Antonia F. Demleitner, S. Adachi, Lisa Neuenroth, Clara Meijs et autres

The diagnosis of Amyotrophic Lateral Sclerosis (ALS) remains challenging, particularly in early stages, where characteristic symptoms may be subtle and nonspecific. The development of disease-specific and clinically validated biomarkers is crucial to optimize diagnosis. Here, we explored tear fluid (TF) as a …

de, au (code pays fourni par la source)

Identification of a presymptomatic and early disease signature for amyotrophic lateral sclerosis (ALS): protocol of the premodiALS study

Laura Tzeplaeff, Ana Galhoz, Clara Meijs, Lucas Caldi Gomes et autres

INTRODUCTION: The median time to diagnosis of amyotrophic lateral sclerosis (ALS) is approximately 12 months after the onset of first symptoms. This diagnostic delay is primarily due to the nonspecific nature of early symptoms and the clinical challenges in differentiating ALS from …

de, sk, tr, ch, fr, us, se, pl, au, il (code pays fourni par la source)

An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes

Antonia F. Demleitner, Lucas Caldi Gomes, Lara Wenz, Laura Tzeplaeff et autres

Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) are neurodegenerative disorders diagnosed by clinical criteria with limited diagnostic specificity in early stages. Diagnostic biomarkers facilitating early and precise diagnosis are needed. Tear fluid (TF) is an easily accessible …

de (code pays fourni par la source)

Identification of a presymptomatic and early disease signature for Amyotrophic Lateral Sclerosis (ALS): protocol of the premodiALS study

Laura Tzeplaeff, Ana Galhoz, Clara Meijs, Lucas Caldi Gomes et autres

The median time to diagnosis of amyotrophic lateral sclerosis (ALS) is approximately 12 months after the onset of first symptoms. This diagnostic delay is primarily due to the nonspecific nature of early symptoms and the clinical challenges in differentiating ALS from its …

de, sk, tr, ch, fr, us, se, pl, au, il (code pays fourni par la source)

Differential tear fluid miRNAs in patients with Parkinson’s disease and atypical Parkinsonian syndromes

Antonia F. Demleitner, Lucas Caldi Gomes, Lara Wenz, Laura Tzeplaeff et autres

de (code pays fourni par la source)

Identification and Validation of a Tear Fluid-Derived Protein Biomarker Signature in Patients with Amyotrophic Lateral Sclerosis

Antonia F. Demleitner, S. Adachi, Lisa Neuenroth, Clara Meijs et autres

de, au (code pays fourni par la source)

AAV-Mediated Expression of miR-17 Enhances Neurite and Axon Regeneration In Vitro

Raquel Alves Almeida, Carolina Gomes Ferreira, Victor Ulysses Souza Matos, Júlia Meireles Nogueira et autres

Neurodegenerative disorders, including traumatic injuries to the central nervous system (CNS) and neurodegenerative diseases, are characterized by early axonal damage, which does not regenerate in the adult mammalian CNS, leading to permanent neurological deficits. One of the primary causes of the loss …

br, de (code pays fourni par la source)

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri et autres

Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective disease-modifying treatments. This study utilizes a comprehensive multiomic approach to investigate the early and sex-specific molecular mechanisms underlying ALS. By analyzing the prefrontal cortex of 51 patients with sporadic …

de, it, fr, nl, ch, pl (code pays fourni par la source)

Metal dyshomeostasis in the substantia nigra of patients with Parkinson's disease or multiple sclerosis

Asunción Carmona, Eleonora Carboni, Lucas Caldi Gomes, Stéphane Roudeau et autres

Abnormal metal distribution in vulnerable brain regions is involved in the pathogenesis of most neurodegenerative diseases, suggesting common molecular mechanisms of metal dyshomeostasis. This study aimed to compare the intra- and extra-neuronal metal content and the expression of proteins related to metal …

fr, de (code pays fourni par la source)

A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis

Fabian Hausmann, Lucas Caldi Gomes, Sonja Hänzelmann, Robin Khatri et autres

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, which still lacks effective disease-modifying therapies. Similar to other neurodegenerative disorders, such as Alzheimer and Parkinson disease, ALS pathology is presumed to propagate over time, originating from the motor cortex and …

de, fr, it, nl, ch (code pays fourni par la source)

msqrob2PTM: Differential Abundance and Differential Usage Analysis of MS-Based Proteomics Data at the Posttranslational Modification and Peptidoform Level

Nina Demeulemeester, Marie Gébelin, Lucas Caldi Gomes, Paul Lingor et autres

In the era of open-modification search engines, more posttranslational modifications than ever can be detected by LC-MS/MS-based proteomics. This development can switch proteomics research into a higher gear, as PTMs are key in many cellular pathways important in cell proliferation, migration, metastasis, …

be, fr, de (code pays fourni par la source)