Robin Khatri

A spatial in situ hybridization approach to T cell clonotype analysis using T cell receptor variable gene probes

Cedric Ly, Darius P. Schaub, Robin Khatri, Zeba Sultana et autres

Resolving T cell clonality at single-cell spatial resolution remains a major challenge. Here, we developed an in situ hybridization panel comprising probes for immune and tissue cell types alongside comprehensive coverage of TRAV, TRBV, TRGV, and TRDV gene segments, enabling unbiased spatial …

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A Methylation-Derived Neural Signature Identifies IDH-wildtype Glioblastomas that Benefit from Supramaximal Resection: A Two-Cohort Biomarker Analysis and a Prospective Intraoperative Nanopore Feasibility Study (EpiGuide)

Franz Lennard Ricklefs, Robin Khatri, László Bárány, Yahya Zghaibeh et autres

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A systematic analysis of the impact of data variation on AI-based histopathological grading of prostate cancer

Patrick Fuhlert, Fabian Westhaeusser, Esther Dietrich, Maximilian Lennartz et autres

The histopathological evaluation of biopsies by human experts is a gold standard in clinical disease diagnosis. While recent artificial intelligence-based (AI) approaches have reached human expert-level performance, they often display shortcomings caused by variations in sample preparation, limiting clinical applicability. This study …

de, se, dk (code pays fourni par la source)

CNSC-61. NEURAL SIGNATURE DISTINGUISHES SILENT FROM OVERT PHENOTYPE IN CORTICOTROPIC PITNETS

Alice Senta Ryba, Matthias Dottermusch, Robin Khatri, Lasse Dührsen et autres

Abstract Corticotroph pituitary neuroendocrine tumors (PitNETs) expressing adrenocorticotropic hormone (ACTH) can lead to Cushing’s disease (CD). In contrast, silent corticotroph PitNETs also produce ACTH but lack clinical or biochemical signs of hypercortisolism and have been associated with a more aggressive clinical course. …

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Granzyme K-Expressing CD8+ T Cells Drive Complement Activation and Tissue Damage in ANCA-Associated Glomerulonephritis

Ulf Panzer, Nariaki Asada, Huiying Wang, Zeba Sultana et autres

Background: ANCA–associated vasculitis is a systemic autoimmune disease and the most common cause of rapidly progressive GN (ANCA-GN). Recent experimental and clinical studies highlight the critical role of the complement system in the pathogenesis of ANCA-GN, but the underlying molecular mechanisms driving …

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Type I Interferon Signature Distinguishes ANCA-Associated Vasculitis Phenotypes and Predicts Kidney Prognosis

Benoît Brilland, Maïa Despré, Robin Khatri, Thomas Quéméneur et autres

Background: ANCA-associated vasculitis (AAV) causes severe multisystemic organ damage. The main phenotypes, microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), share similarities but differ in clinical presentation and outcome. To uncover their molecular differences, we performed transcriptomic profiling of kidney tissue, then …

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Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh et autres

Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney diseases and is characterized by glomerular crescent formation with proliferation of parietal epithelial cells (PECs). However, the underlying mechanisms of glomerular crescent formation are incompletely understood. Here we provide a …

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A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis

Benoît Brilland, Maïa Despré, Robin Khatri, Thomas Quéméneur et autres

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Spatial Analysis of T Cell Clonality in Autoimmune Kidney Disease Using TRV Probes

Cedric Ly, Darius P. Schaub, Robin Khatri, Zeba Sultana et autres

Abstract Hypothesizing that the localization of T cell clones correlates with immune function, our goal was to develop an unbiased method to study the spatial distribution of T cells in tissues. We created an in situ hybridization panel with 248 probes that …

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Personalized Genotype‐Based Approach for Treatment of Phenylketonuria

Polina Gundorova, Behnam Yousefi, Mathias Woidy, Malcolm Summer Rose‐Heine et autres

Extensive studies have examined the clinical manifestations, pathogenic mechanisms, and genetic variations of phenylketonuria (PKU) across different populations, resulting in a substantial collection of molecular genetic data on the phenylalanine hydroxylase (PAH) gene and its variants. However, many genotypes are associated with …

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In-depth assessment of BRAF, NRAS, KRAS, EGFR, and PIK3CA mutations on cell-free DNA in the blood of melanoma patients receiving immune checkpoint inhibition

Isabel Heidrich, Charlotte Rautmann, Cedric Ly, Robin Khatri et autres

Abstract Introduction Circulating tumor DNA (ctDNA) holds promise for guiding immune checkpoint inhibitor (ICI) therapy and stratifying responders from non-responders. While tumor-informed ctDNA detection approaches are sensitive and mutation-inclusive, they require tumor tissue, which limits applicability in real-world settings. Conversely, tumor-agnostic methods …

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SCALE: Unsupervised Multi-Scale Domain Identification in Spatial Omics Data

Behnam Yousefi, Darius P. Schaub, Robin Khatri, Nico Kaiser et autres

Single-cell spatial transcriptomics enables precise mapping of cellular states and functional domains within their native tissue environment. These functional domains often exist at multiple spatial scales, with larger domains encompassing smaller ones, reflecting the hierarchical organization of biological systems. However, the identification …

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