Luuk Hilgers

Carbohydrate fatty acid monosulphate ester adjuvant enhances the immunogenicity of influenza antigens via TLR4/2-dependent mechanisms

Sruthi Vijaya Retnakumar, Suraj Chandrabhan Singh, Srinivasa Reddy Bonam, Camille Chauvin et autres

Introduction: Subunit influenza vaccines require potent adjuvants to elicit robust and broad immune responses, particularly against emerging pandemic strains such as H7N9. However, currently approved adjuvants often fail to induce durable and broadly protective immunity. Carbohydrate fatty acid monosulphate ester (CMS), a …

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A Novel Carbohydrate Fatty-Acid Monosulphate Ester, Squalane-in-Water Adjuvant Is Safe and Enhances Inactivated Influenza Vaccine Immunogenicity in Older Adults

Valentino D’Onofrio, Bart Jacobs, Azhar Alhatemi, Simon De Gussem et autres

Influenza vaccines are the primary strategy to prevent severe influenza disease; however, their efficacy is often suboptimal, particularly in older adults (OAs). LiteVax Adjuvant (LVA), a novel adjuvant containing carbohydrate fatty-acid monosulphate ester (CMS) as the active ingredient, has demonstrated a favourable …

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Improving the immunogenicity of the pneumococcal conjugate vaccine using a synthetic carbohydrate fatty acid monosulphate squalane-in-water adjuvant

Lucille F. van Beek, Christa E. van der Gaast‐de Jongh, Peter Paul Platenburg, Luuk Hilgers et autres

Pneumococcal conjugate vaccines (PCVs) have been highly effective in preventing invasive pneumococcal disease. However, increasing serotype coverage of PCVs led to decreasing antibody responses against individual serotypes, possibly leading to vaccine failure. It is therefore important to improve the immunogenicity of PCVs. …

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Safety and Immunogenicity of a Carbohydrate Fatty Acid Monosulphate Ester Adjuvant Combined with a Low-Dose Quadrivalent Split-Virion Inactivated Influenza Vaccine: A Randomised, Observer-Blind, Active-Controlled, First-in-Human, Phase 1 Study

Valentino D’Onofrio, Sharon Porrez, Bart Jacobs, Azhar Alhatemi et autres

Seasonal influenza vaccine effectiveness is low. Carbohydrate fatty acid monosulphate ester (CMS), a new oil-in-water adjuvant, has proven potency in animal models with suggested capacity for dose-sparing. The objective was to evaluate safety and immunogenicity of CMS when added to a low-dose …

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Immunogenicity and safety in rabbits of a Clostridioides difficile vaccine combining novel toxoids and a novel adjuvant

Aria Aminzadeh, Luuk Hilgers, Peter Paul Platenburg, Mickaël Riou et autres

Clostridioides difficile infection (CDI) is a serious healthcare-associated disease, causing symptoms such as diarrhea and pseudomembranous colitis. The major virulence factors responsible for the disease symptoms are two secreted cytotoxic proteins, TcdA and TcdB. A parenteral vaccine based on formaldehyde-inactivated TcdA and …

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Carbohydrate fatty acid monosulphate ester is a potent adjuvant for low-dose seasonal influenza vaccines

Peter Paul Platenburg, Frantz S. Deschamps, Jennifer Jung, Clément Léonard et autres

(3 µg of HA) a licensed seasonal flu vaccine with the novel carbohydrate fatty acid monosulfate ester (CMS)-based adjuvant was investigated in ferrets and safety in rabbits. Without CMS, hemagglutination inhibition (HI) antibody titers ranged from ≤5 to 26 three weeks post …

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Vaccine safety of a new toxoid-based vaccine against Clostridioides difficile infection in rabbits

Aria Aminzadeh, Mickaël Riou, Luuk Hilgers, Peter Paul Platenburg et autres

National audience

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Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Etsuro Nanishi, Francesco Borriello, Hyuk‐Soo Seo, Timothy R. O’Meara et autres

In this article Hyuk-Soo Seo, Timothy R. O’Meara, Marisa E. McGrath was incorrectly denoted as being one of the equally contributing authors. The original article has been corrected.

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Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Etsuro Nanishi, Francesco Borriello, Hyuk‐Soo Seo, Timothy R. O’Meara et autres

Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies and protection in young and aged mice. …

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Carbohydrate Fatty Acid Monosulphate Ester is a Potent Adjuvant for Low-Dose Seasonal Influenza Vaccines

Peter Paul Platenburg, Frantz S. Deschamps, Jennifer Jung, Clément Léonard et autres

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An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

Francesco Borriello, Etsuro Nanishi, Hyuk‐Soo Seo, Timothy R. O’Meara et autres

SUMMARY Development of affordable and effective vaccines that can also protect vulnerable populations such as the elderly from COVID-19-related morbidity and mortality is a public health priority. Here we took a systematic and iterative approach by testing several SARS-CoV-2 protein antigens and …

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Carbohydrate fatty acid monosulphate esters are safe and effective adjuvants for humoral responses

Luuk Hilgers, Peter Paul Platenburg, Jeffrey John Bajramovic, Jennifer Veth et autres

Carbohydrate fatty acid sulphate esters (CFASEs) formulated in a squalane-in-water emulsion are effective adjuvants for humoral responses to a wide range of antigens in various animal species but rise in body temperature and local reactions albeit mild or minimal hampers application in …

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