Judith M. de Bont

M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors

Kyle S. Smith, Tom T. Fischer, Katie Han, Anna Kostecka et autres

Cerebrospinal fluid (CSF) liquid biopsies serve as a rich source of tumor-derived cell-free DNA (cfDNA) for evaluating persons with central nervous system (CNS) tumors. However, challenges stemming from trace cfDNA yields and low mutational burden have hindered sensitivity, whereas first-generation clinical assays …

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Long-term quality of survival after pediatric low-grade glioma

Judith M. de Bont, Antoinette Y. N. Schouten‐van Meeteren

nl (code pays fourni par la source)

Mineralocorticoid receptor status in the human brain after dexamethasone treatment: a single case study

Anne-Sophie C A M Koning, Philippe C. Habets, Marit Bogaards, Jan Kroon et autres

Background: Synthetic glucocorticoids like dexamethasone can cause severe neuropsychiatric effects. They preferentially bind to the glucocorticoid receptor (GR) over the mineralocorticoid receptor (MR). High dosages result in strong GR activation but likely also result in lower MR activation based on GR-mediated negative …

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The importance of specialized sleep investigations in children with a suprasellar tumor

Jiska van Schaïk, Sigrid Pillen, Raphaële R. L. van Litsenburg, Nele Vandenbussche et autres

PURPOSE: Disruption of sleep has great impact on quality of life. In children with a suprasellar tumor and hypothalamic-pituitary dysfunction, the circadian rhythm may be disturbed causing sleep problems. However, also other factors may influence sleep. Awareness of these different etiologies and …

nl (code pays fourni par la source)

Biological Markers in Pediatric Brain Tumors

Judith M. de Bont

textabstractThe most common solid tumors in children are brain tumors1. Yearly, approximately 2-2.5 per 100,000 children of <15 years of age are diagnosed with a brain tumor1. Despite improved survival rates, brain tumors in children are still the second leading cause of …

Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective

Judith M. de Bont, Roger J. Packer, Erna M. C. Michiels, Monique L. den Boer et autres

Survival rates of pediatric brain tumor patients have significantly improved over the years due to developments in diagnostic techniques, neurosurgery, chemotherapy, radiotherapy, and supportive care. However, brain tumors are still an important cause of cancer-related deaths in children. Prognosis is still highly …

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Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis

Judith M. de Bont, Johan M. Kros, Monique Passier, Roel E. Reddingius et autres

The objective of this study was to identify differentially expressed and prognostically important genes in pediatric medulloblastoma and pediatric ependymoma by Affymetrix microarray analysis. Among the most discriminative genes, three members of the SOX transcription factor family were differentially expressed. Both SOX4 …

nl (code pays fourni par la source)

Various components of the insulin‐like growth factor system in tumor tissue, cerebrospinal fluid and peripheral blood of pediatric medulloblastoma and ependymoma patients

Judith M. de Bont, Jaap van Doorn, Roel E. Reddingius, Gerard H.M. Graat et autres

The insulin-like growth factor (IGF) system plays an important role in neuronal development and may contribute to the development of brain tumors. In this study, we studied mRNA expression levels of IGFs, insulin-like growth factor binding proteins (IGFBPs) and insulin-like growth factor …

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Increased total-Tau levels in cerebrospinal fluid of pediatric hydrocephalus and brain tumor patients

Judith M. de Bont, Hugo Vanderstichele, Roel E. Reddingius, Rob Pieters et autres

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Identification of Novel Biomarkers in Pediatric Primitive Neuroectodermal Tumors and Ependymomas by Proteome-Wide Analysis

Judith M. de Bont, Monique L. den Boer, Johan M. Kros, Monique Passier et autres

The aim of this study was to identify aberrantly expressed proteins in pediatric primitive neuroectodermal tumors (PNETs) and ependymomas. Tumor tissue of 29 PNET and 12 ependymoma patients was subjected to 2-dimensional difference gel electrophoresis. Gel analysis resulted in 79 protein spots …

nl (code pays fourni par la source)

Identification of Apolipoprotein A-II in Cerebrospinal Fluid of Pediatric Brain Tumor Patients by Protein Expression Profiling

Judith M. de Bont, Monique L. den Boer, Roel E. Reddingius, Jaap Jansen et autres

BACKGROUND: Our aim was to detect differences in protein expression profiles of cerebrospinal fluid (CSF) from pediatric patients with and without brain tumors. METHODS: We used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry and Q10 ProteinChip arrays to compare protein expression profiles …

nl (code pays fourni par la source)

CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia

Laura J. C. M. van Zutven, Ellen van Drunen, Judith M. de Bont, M M Wattel et autres

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