Rohit Menon

Paternal social fear conditioning drives sex-specific behavioral alterations and septal gene regulation

Laura Stangl, Anna Bludau, Virginie Rappeneau, Rohit Menon

Abstract The intergenerational transmission of traumatic experiences is increasingly recognized as a contributor to behavioral and neurobiological vulnerability in offspring. However, the inheritance of paternal traumatic social experiences remains poorly understood. Here, we employed the social fear conditioning (SFC) paradigm in mice …

de (code pays fourni par la source)

Oxytocin receptor Gαi signaling drives valence reassignment to facilitate reversal of social trauma-induced avoidance

Theresa Schaefer, David Keller, Francisco De los Santos, Anna Bludau et autres

Abstract Traumatic social experiences often generate social deficits that form the core symptom of psychopathologies like social anxiety disorder (SAD). The failure to overwrite these aversive social associations is a fundamental barrier to recovery from SAD. Using the mouse social fear conditioning …

de (code pays fourni par la source)

Spliceread: improving canonical and non-canonical splice site prediction with residual blocks and synthetic data augmentation

Sahil Thapa, Khushali Samderiya, Rohit Menon, Oluwatosin Oluwadare

Accurate splice site prediction is fundamental to understanding gene expression and its associated disorders. However, most existing models are biased toward frequent canonical sites, limiting their ability to detect rare but biologically important non-canonical variants. These models often rely heavily on large, …

us (code pays fourni par la source)

Paternal social fear conditioning drives sex-specific behavioral alterations and septal gene regulation

Laura Stangl, Anna Bludau, Virginie Rappeneau, Rohit Menon

de (code pays fourni par la source)

Acute and persistent neuroendocrine and behavioral alterations after social fear conditioning in adolescent male mice

Anna Bludau, Melanie Kabas, Rohit Menon, Inga D. Neumann

Adolescence is a critical developmental period with heightened stress susceptibility. Traumatic experiences during this phase are highly predictive of future affective disorders, such as social anxiety disorder (SAD), which may manifest during early adolescence. Social avoidance, a major symptom of SAD, can …

Acute and persistent neuroendocrine and behavioral alterations after social fear conditioning in adolescent male mice

Anna Bludau, Melanie Kabas, Rohit Menon, Inga D. Neumann

Abstract Adolescence is a critical developmental period with heightened stress susceptibility. Traumatic experiences during this phase are highly predictive of future affective disorders, such as social anxiety disorder (SAD), which may manifest during early adolescence. Social avoidance, a major symptom of SAD, …

de (code pays fourni par la source)

The Heartbeat that Hesitates

Rohit Menon

us (code pays fourni par la source)

SpliceRead: Improving Canonical and Non-Canonical Splice Site Prediction with Residual Blocks and Synthetic Data Augmentation

Sahil Thapa, Khushali Samderiya, Rohit Menon, Oluwatosin Oluwadare

Accurate splice site prediction is fundamental to understanding gene expression and its associated disorders. However, most existing models are biased toward frequent canonical sites, limiting their ability to detect rare but biologically important non-canonical variants. These models often rely heavily on large, …

us (code pays fourni par la source)

Sex-dependent involvement of lateral septum astrocytes in social fear: Role of oxytocin receptor signaling

Laura Boi, Rohit Menon, Clémence Denis, Kai-Yi Wang et autres

Abstract Astrocytes are now widely recognized as important modulators of synaptic plasticity and socio-emotional behaviors. Recent studies highlight their involvement in anxiety- and depressive-like behaviors, particularly via oxytocin (OXT) signaling. While the specific contributions of astrocytes remain largely unexplored, the role of …

de, fr (code pays fourni par la source)

Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder

Laura Boi, Rohit Menon, Barbara Di Benedetto

de (code pays fourni par la source)

Astrocyte Morphological Adaptations in a Mouse Model of Social Anxiety Disorder

Laura Boi, Rohit Menon, Barbara Di Benedetto

The social fear conditioning (SFC) paradigm, which is an animal model of social anxiety disorder, has been extensively used to investigate the cellular and molecular mechanisms underlying the psychopathology of this disorder. Studies using the SFC paradigm have suggested that the lateral …

de (code pays fourni par la source)

Mating-induced release of oxytocin in the mouse lateral septum: Implications for social fear extinction

Cindy P. Grossmann, Christoph Markus Sommer, Ilayda Birben Fahliogullari, Inga D. Neumann et autres

In mammals, some physiological conditions are associated with the high brain oxytocin (OXT) system. These include lactation in females and mating in males and females, both of which have been linked to reduced stress responsiveness and anxiolysis. Also, in a murine model …

de (code pays fourni par la source)