NISAR P. MALEK

Phenotypic Heterogeneity in Crohn’s Disease-Associated Intestinal Strictures: An Exploratory Retrospective Cohort Study

Stefano Fusco, Juliette Nesseler, Lisa Minn, Sabrina Groß et autres

Background: Crohn’s disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn’s disease demonstrate substantial clinical heterogeneity regarding disease localization, penetrating complications, systemic manifestations, metabolic alterations, and treatment exposure. This study …

de (code pays fourni par la source)

SAT-158-YI Epigenetic maintenance by DNMT1 safeguards the liver from inflammatory and fibrotic injury in MASLD/MASH

Lina Jegodzinski, Darko Castven, Juliana Marques Affonso, Diana Becker et autres

Precision oncology in primary liver cancer: Bridging the gap between molecular profiling and patient benefit

M Bitzer, NISAR P. MALEK

de (code pays fourni par la source)

The versatile interplay between steatotic liver disease and liver cancer

Mohammad Rahbari, Albert Gris‐Oliver, Pierluigi Ramadori, David Aicher et autres

de, es, us (code pays fourni par la source)

Personalized signaling pathway analysis of gastrointestinal tumors for patient stratification and drug target evaluation using clinically derived core biopsies

Aaron Stahl, Karsten Büringer, Pavlos Missios, Tatjana Hoffmann et autres

Aberrant cellular signaling underlies cancer development and progression. Identifying alterations in these pathways yields critical insights for personalized oncology. Clinically, assessing the activation status of signaling proteins complements genetic and histopathological analyses, improving therapeutic evaluation and accuracy. In this study, we employed …

de (code pays fourni par la source)

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance

Xin Li, Cynthia Lebeaupin, Aikaterini Kadianaki, Clementine Druelle-Cedano et autres

Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies 1 . Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains …

de, us, es, ch, cn (code pays fourni par la source)

Targeting of p53-Transcriptional Dysfunction by Conditionally Replicating Adenovirus Is Not Limited by p53-Homologues

Florian Kühnel, Engin Gürlevik, Thomas C. Wirth, Nina Strüver et autres

Clinical outcome of biomarker-guided therapies in adult neuro-oncology patients: An update from the Tübingen molecular tumor board cohort

David Rieger, Hannes Becker, Bianca Walter, Lorenz Dörner et autres

Background: Molecular profiling and subsequent discussions in the Molecular Tumor Board (MTB) within the network of Centers for Personalized Medicine (CPM) have expanded therapeutic options for neuro-oncology patients. Here, we present an update of our Tübingen MTB cohort in adult patients with …

de (code pays fourni par la source)

Epidemiology and Genotyping of Patients with Chronic Hepatitis B: Genotype Shifting Observed in Patients from Central Europe

ALFRED L. BISSINGER, CHRISTOF FEHRLE, CHRISTOPH R. WERNER, Ulrich M. Lauer et autres

Background: Knowledge on HBV prevalence and genotype distribution in Europe still is hampered by lack of coherent data sampling, small numbers of patients studied so far, and also modern times migration which influences both parameters in a quite dynamic manner. To find …

de (code pays fourni par la source)