James Cain

Transcriptional interference drives intronic polyadenylation at the endogenous H13/Mcts2 locus

James Cain, Chuying Yang, Hallgerdur Kolbeinsdottir, Anne-Valérie Gendrel et autres

Over a tenth of mammalian genes are nested within other host genes, raising the question of how both can be co-expressed when concurrent transcription occurs in overlapping genetic space. DNA methylation at nested intragenic CpG island promoters can prevent such conflict by …

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Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay

Bertille Montibus, James Cain, Rocío T. Martínez-Nuñez, Rebecca J. Oakey

Nucleotide sequences along a gene provide instructions to transcriptional and cotranscriptional machinery allowing genome expansion into the transcriptome. Nucleotide sequence can often be shared between two genes and in some occurrences, a gene is located completely within a different gene; these are …

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The Intellectual Disability Risk GeneKdm5bRegulates Long-Term Memory Consolidation in the Hippocampus

Leticia Pérez‐Sisqués, S. Bhatt, Rugilė Matulevičiūtė, Talia Gileadi et autres

The histone lysine demethylase KDM5B is implicated in recessive intellectual disability disorders, and heterozygous, protein-truncating variants inKDM5Bare associated with reduced cognitive function in the population. The KDM5 family of lysine demethylases has developmental and homeostatic functions in the brain, some of which …

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Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplay

Bertille Montibus, James Cain, Rocío T. Martínez-Nuñez, Rebecca J. Oakey

ABSTRACT Nucleotide sequences along a gene provide instructions to transcriptional and co-transcriptional machinery allowing genome expansion into the transcriptome. Interestingly, nucleotide sequence can often be shared between two genes and in some occurrences, a gene is located completely within a different gene, …

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Intragenic CpG Islands and Their Impact on Gene Regulation

James Cain, Bertille Montibus, Rebecca J. Oakey

The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene promoters. Advances in genomic annotations …

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High-throughput parallel synthesis optimization of Glucagon-like Peptide 1 receptor agonists

Cyf Ramos‐Colon, Andrew Kennedy, James Cain

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Synthesis of an HIV-targeted stapled peptide: Fully automated on-resin peptide cyclization via olefin metathesis

James Cain, Daniel Martínez, Andrew Kennedy, Cyf Ramos‐Colon

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Therapeutic Peptides: Synthesis Optimization Using Parallel Automated SPPS

Andrew Kennedy, James Cain, Cyf Ramos‐Colon, Daniel Martínez

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Design of novel melanocortin receptor ligands: Multiple receptors, complex pharmacology, the challenge

Victor J. Hruby, Minying Cai, James Cain, Joel Nyberg et autres

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Dry etch sequencing induced gate oxide degradation due to metallic contamination in 0.25 μm CMOS manufacturing

J.B. Hughes, A.H. Perera, I. Hernández, Sanjay Parihar et autres

To ensure maximum tool utilization in high volume semiconductor manufacturing, multiple etch recipes may be implemented on a given etch chamber configuration. Due to the increased process complexity required for 0.25 /spl mu/m semiconductor fabrication, residual effects in chambers and interaction between …

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Understanding the transcriptional interplay at host/nested gene pairs

James Cain