Jenny Y. Zhang

Integration of the naive pluripotency gene network with the response to GSK3 inhibition by Tcf7l1-driven enhancer decommissioning

Jieun Kwon, Jenny Y. Zhang, Brian R. Shy, Matthew S. MacDougall et autres

The transition out of naive pluripotency requires the simultaneous dissolution of the naive gene regulatory network as well as a redirection of transcriptional response to WNT/β-CATENIN signaling. Here, we show that Tcf7l1 functions as a linchpin factor that connects the two outcomes …

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Response of Candida albicans white and opaque cells to phagocytosis by macrophages suggests that opaque cells are “pre-adapted”

Matthew B. Lohse, Megan E. Garber, Haley Gause, Jenny Y. Zhang et autres

ABSTRACT Candida albicans is a normal resident of the human gut and mucosal microbiomes and also an opportunistic fungal pathogen. It undergoes several morphological transitions, one of which is white-opaque switching, where C. albicans reversibly alternates between two distinct cell types, namely, …

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Editor’s Note: A Novel L -Asparaginase with low L -Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo

Hien Anh Thi Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic et autres

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AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

Daphne F. Chen, Leah Tang Roe, Yuping Li, Adair L. Borges et autres

ABSTRACT Phage-encoded anti-CRISPR (Acr) proteins inhibit CRISPR-Cas systems, allowing phage replication and lysogeny maintenance. Most of the Acrs characterized to date are stable stoichiometric inhibitors. While enzymatic Acrs have been characterized biochemically, little is known about their potency, specificity, and reversibility. Here, …

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AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

Daphne F. Chen, Leah Tang Roe, Yuping Li, Adair L. Borges et autres

Abstract Phage-encoded anti-CRISPR (Acr) proteins inhibit CRISPR-Cas systems to allow phage replication and lysogeny maintenance. Most of the Acrs characterized to date are stable stoichiometric inhibitors. While enzymatic Acrs have been characterized biochemically, little is known about their potency, specificity, and reversibility. …

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Author Response: Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

Anne L. Sapiro, Beth M. Hayes, Regan F. Volk, Jenny Y. Zhang et autres

Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.

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Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

Anne L. Sapiro, Beth M. Hayes, Regan F. Volk, Jenny Y. Zhang et autres

Borrelia burgdorferi ( Bb ), the causative agent of Lyme disease, adapts to vastly different environments as it cycles between tick vector and vertebrate host. During a tick bloodmeal, Bb alters its gene expression to prepare for vertebrate infection; however, the full …

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Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

Anne L. Sapiro, Beth M. Hayes, Regan F. Volk, Jenny Y. Zhang et autres

Abstract Borrelia burgdorferi (Bb), the causative agent of Lyme disease, adapts to vastly different environments as it cycles between tick vector and vertebrate host. During a tick bloodmeal, Bb alters its gene expression to prepare for vertebrate infection; however, the full range …

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Author Response: Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

Anne L. Sapiro, Beth M. Hayes, Regan F. Volk, Jenny Y. Zhang et autres

Borrelia burgdorferi (Bb), the causative agent of Lyme disease, adapts to vastly different environments as it cycles between tick vector and vertebrate host. During a tick bloodmeal, Bb alters its gene expression to prepare for vertebrate infection; however, the full range of …

us (code pays fourni par la source)

Supplementary Data from A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo

Hien Anh Thi Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic et autres

Supplementary methods Supplementary Text: Wolinella succinogenes as a low L-glutaminase L-asparaginase Supplementary Figures: • Fig. S1. In vivo imaging showing that the L-glutaminase-diminished ErA-63Q and ErA-DM variants eliminate T-ALL LOUCY cells as effectively as the high L-glutaminase ErA-WT. • Fig. S2: In …

Data from A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo

Hien Anh Thi Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic et autres

Abstract Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL cells. …

Supplementary Data from A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo

Hien Anh Thi Nguyen, Ying Su, Jenny Y. Zhang, Aleksandar Antanasijevic et autres

Supplementary methods Supplementary Text: Wolinella succinogenes as a low L-glutaminase L-asparaginase Supplementary Figures: • Fig. S1. In vivo imaging showing that the L-glutaminase-diminished ErA-63Q and ErA-DM variants eliminate T-ALL LOUCY cells as effectively as the high L-glutaminase ErA-WT. • Fig. S2: In …