Panhong Liu

Chinese Immune Multi-Omics Atlas

Jianhua Yin, Yuhui Zheng, Zhuoli Huang, Wenwen Zhou et autres

Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetic variants through multi-omics analysis of more than 10 million …

cn, hk, sg (code pays fourni par la source)

Cell-free DNA as a potential alternative to genomic DNA in genetic studies

Jingyu Zeng, Huanhuan Zhu, Yu Wang, Guodan Zeng et autres

Next-generation sequencing has greatly advanced genomics, enabling large-scale studies of population genetics and complex traits. Genomic DNA (gDNA) from white blood cells has traditionally been the main data source, but cell-free DNA (cfDNA), found in bodily fluids as fragmented DNA, is increasingly …

cn, Botswana (code pays fourni par la source)

Novel insights into the genetic architecture of pregnancy glycemic traits from 14,744 Chinese maternities

Huanhuan Zhu, Xiao Han, Linxuan Li, Meng Yang et autres

Glycemic traits are critical indicators of maternal and fetal health during pregnancy. We performed genetic analysis for five glycemic traits in 14,744 Chinese pregnant women. Our genome-wide association study identified 25 locus-trait associations, including established links between gestational diabetes mellitus (GDM) and …

cn, Botswana (code pays fourni par la source)

Genetic analyses of 104 phenotypes in 20,900 Chinese pregnant women reveal pregnancy-specific discoveries

Xiao Han, Linxuan Li, Meng Yang, Xinyi Zhang et autres

Monitoring biochemical phenotypes during pregnancy is vital for maternal and fetal health, allowing early detection and management of pregnancy-related conditions to ensure safety for both. Here, we conducted a genetic analysis of 104 pregnancy phenotypes in 20,900 Chinese women. The genome-wide association …

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An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms

Wenbo Sun, Tingyu Yang, Fengming Sun, Panhong Liu et autres

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MA‐ResUNet: Multi‐attention optic cup and optic disc segmentation based on improved U‐Net

Xiaoqian Zhang, Ying Lin, Linxuan Li, Jingyu Zeng et autres

Abstract Glaucoma poses a significant threat to vision, capable of causing irreversible damage and, in severe instances, leading to permanent blindness. Accurate optic cup (OC) and optic disc (OD) segmentation are essential in glaucoma screening. In this study, a novel OC and …

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Genetic analysis of 104 pregnancy phenotypes in 39,194 Chinese women

Han Xiao, Linxuan Li, Meng Yang, Jingyu Zeng et autres

Abstract Maternity is a special period in a woman’s life that involves substantial physiological, psychological, and hormonal changes. These changes may cause alterations in many clinical measurements during pregnancy, which can be used to monitor and diagnose maternal disorders and adverse postnatal …

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Genetic studies of gestational diabetes mellitus in 21,813 Chinese women

Huanhuan Zhu, Han Xiao, Linxuan Li, Meng Yang et autres

Abstract Gestational diabetes mellitus (GDM) is a common complication of pregnancy with adverse effects on both mothers and fetuses. The relationship between GDM and clinical information has been largely investigated; however, the role of laboratory features and genetic components in GDM are …

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The complete and fully-phased diploid genome of a male Han Chinese

Chentao Yang, Yang Zhou, Yanni Song, Dongya Wu et autres

Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual (CN1), …

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Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19

Yuwen Pan, Panhong Liu, Fang Wang, Peng Wu et autres

Abstract The Angiotensin-Converting Enzyme-2 (ACE2) gene, located on Xp22.2, attracts a great deal of attention because the protein it encodes is believed to be the functional cellular receptor for the new coronavirus (SARS-CoV-2). However, recent studies are controversial, especially concerning the intrinsic …

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Rare Variants in Inborn Errors of Immunity Genes Associated With Covid-19 Severity

Panhong Liu, Mingyan Fang, Yuxue Luo, Fang Zheng et autres

Host genetic factors have been shown to play an important role in SARS-CoV-2 infection and the course of Covid-19 disease. The genetic contributions of common variants influencing Covid-19 susceptibility and severity have been extensively studied in diverse populations. However, the studies of …

cn, sg, hk (code pays fourni par la source)

Rare Variants in Inborn Errors of Immunity Genes Associated with Covid-19 Severity

Panhong Liu, Mingyan Fang, Yuxue Luo, Zheng Fang et autres

Abstract Covid-19 is a contagious disease caused by SARS-CoV-2, a novel severe acute respiratory syndrome coronavirus. Common variants and networks underlying host genetic mechanisms have been extensively studied to identify disease-associated genetic factors. However, there are few studies about the rare variants, …

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