Brendan Cord Lethebe

Clinical and Radiologic Characteristics of Familial Pulmonary Fibrosis

Amanda Grant-Orser, Daniel-Costin Marinescu, Cameron Hague, Nestor L Muller et autres

RATIONALE: Familial pulmonary fibrosis (FPF), defined as fibrosing interstitial lung disease (ILD) affecting two or more family members, is associated with earlier-onset and a more aggressive disease phenotype. Imaging findings may vary between relatives, complicating diagnosis. While genetic testing exists, it is …

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The effect of calendar month on tic severity in children and youth with Tourette syndrome

Isabella Davenport, Brendan Cord Lethebe, Catherine Deans, Davide Martino et autres

Background Known influences on tic severity include medical, biological and contextual factors. Aims We aimed to further understanding of contextual factors by exploring if tic severity is influenced by calendar month. Method This study used data from the Calgary Child Tic Registry. …

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Disease Course and Risk of Relapse in Juvenile Localized Scleroderma: A Single‐Center Retrospective Study

Merna Adly, Vimal H. Prajapati, Rebeka Stevenson, Brendan Cord Lethebe et autres

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Prior antibiotic exposure is associated with worse outcomes in adults with COVID-19

Finlay A. McAlister, Meng Lin, Erik Youngson, Brendan Cord Lethebe et autres

BACKGROUND: Antibiotic-induced perturbations of the gut microbiome impair immunologic responses but whether they influence disease severity is unknown. The COVID-19 pandemic provided a unique opportunity to explore this question given widespread testing for SARS-CoV-2 infections. OBJECTIVE: To determine whether prior antibiotic exposure …

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Thrombolysis With Tenecteplase for Minor Disabling Stroke

Yiran Zhang, Brian Buck, Philip A. Barber, Kausik Chatterjee et autres

Importance: Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective: To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score-based definitions of pretreatment disabling deficits. …

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Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Amy Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field et autres

BACKGROUND: In this subanalysis of the TEMPO-2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences …

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Dedicated Automatic Recall Hepatocellular Cancer Surveillance Programme Demonstrates High Retention: A Population‐Based Cohort Study

Mayur Brahmania, Stephen E. Congly, Yashasavi Sachar, Kelly W. Burak et autres

INTRODUCTION: Patient, clinician, and system-related barriers may affect adherence to hepatocellular carcinoma (HCC) surveillance programmes. The impact of a dedicated automated recall HCC surveillance programme on retention rates in patients eligible for screening is unknown. We aimed to describe and evaluate a …

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Low-dose aspirin versus placebo in postpartum venous thromboembolism: a multi-national, pilot, randomised, placebo-controlled trial

Leslie Skeith, Ann Kinga Malinowski, Darine El‐Chaâr, Wee‐Shian Chan et autres

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Adverse events, success, and tolerability of biliary endoscopic retrograde cholangiopancreatography with conscious sedation vs anaesthesia: a multi-centre prospective study

Zachary L. Smith, Ahmed Kayal, Yibing Ruan, Brendan Cord Lethebe et autres

Background and Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is performed using anaesthesia or conscious sedation, though the effectiveness, adverse events (AEs), and tolerability of each approach remain unclear. Thus, we compared these approaches prospectively. Methods: We performed a multi-centre prospective cohort study including …

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Level 4 seizure monitoring unit admissions are associated with reduced long‐term health care costs

Colin B. Josephson, Brendan Cord Lethebe, Elaine L. L. Pang, Fiona Clement et autres

OBJECTIVE: This study was undertaken to determine whether admission to dedicated seizure monitoring units (SMUs) result in reduced health care use (HCU). METHODS: This was a retrospective open cohort study covering the years 2010-2018 of patients residing in Alberta, Canada, who were …

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Clinical and Economic Outcome Analysis of First-Line Immunosuppression in Acquired Hemophilia a

Ellen Cusano, Julia Hews‐Girard, Mujtaba Basharat, Lindsay Cowley et autres

Introduction Acquired hemophilia A (AHA) is a rare bleeding disorder in which inhibitory antibodies neutralize factor VIII (FVIII) activity leading to high morbidity and mortality from both bleeding and complications of immunosuppressive treatment (IST). Individuals with AHA are vulnerable to the adverse …

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Excess health care use is significantly and persistently reduced following diagnosis of late‐onset epilepsy

Marta Berglund, Arturo González-Izquierdo, Spiros Denaxas, Brendan Cord Lethebe et autres

OBJECTIVE: The incidence of late-onset epilepsy (LOE) is rising, and these patients may use an excess of health care resources. This study aimed to measure pre-/post-diagnostic health care use (HCU) for patients with LOE compared to controls. METHODS: This was an observational …

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