Prior antibiotic exposure is associated with worse outcomes in adults with COVID-19
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Le résumé fourni par la source
BACKGROUND: Antibiotic-induced perturbations of the gut microbiome impair immunologic responses but whether they influence disease severity is unknown. The COVID-19 pandemic provided a unique opportunity to explore this question given widespread testing for SARS-CoV-2 infections. OBJECTIVE: To determine whether prior antibiotic exposure was associated with outcomes in patients with COVID-19. METHODS: Retrospective cohort study of all community-dwelling adults in Alberta, Canada with COVID-19 between March 2020 and June 2023. Subjects with antibiotic dispensations in the prior 3 months were compared (using multivariable logistic regression and propensity score (PS)-matching) to those without antibiotic exposure for differences in 30-day outcomes. RESULTS: Of 445,646 adults with COVID-19, 49,581 (11.1%) were exposed to at least one antibiotic course in the prior 3 months. Those exposed to antibiotics were more likely to present to an emergency department (13.4% vs. 7.4%, aOR 1.52, 95%CI 1.48-1.57, PS-matched OR 1.48, 1.42-1.54), be hospitalised (5.8% vs. 2.8%, aOR 1.40,1.33-1.46, PS-matched OR 1.37, 1.29-1.45), or die (1.7% vs. 0.6%, aOR 1.28, 1.18-1.40, PS-matched OR 1.27, 1.14-1.42) than patients without prior antibiotic exposure. The associations were similar whether the antibiotic prescriptions were appropriate or not or whether antibiotic exposure periods were 6 weeks, 6 months, or 12 months prior to the positive RT-PCR test. The associations were stronger in those individuals with the highest tertile of antibiotic exposure, or those exposed to broad-spectrum antibiotics, or younger patients. CONCLUSION: Prior antibiotic exposure is associated with worsened disease severity in patients infected with SARS-CoV-2. These findings support efforts to reduce antibiotic use.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prior antibiotic exposure is associated with worse outcomes in adults with COVID-19
- Date Crossref
- 13/11/2025
- Éditeur
- Informa UK Limited
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Alberta pays non établi dans la noticeUniversité ou école supérieure
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Canadian Patient Safety Institute pays non établi dans la noticeOrganisation à but non lucratif
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Alberta Health Services pays non établi dans la noticeÉtablissement de santé
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University of Calgary pays non établi dans la noticeUniversité ou école supérieure
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Alberta Strategy for Patient Oriented Research Support Unit pays non établi dans la noticeInstitution
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Faculty of Medicine & Dentistry Division of General Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Provincial Research Data Services pays non établi dans la noticeInstitution
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School of Public Policy and Cumming School of Medicine pays non établi dans la noticeUniversité ou école supérieure
University of Alberta, Canadian Patient Safety Institute et Alberta Health Services, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.