Lijun Guo

Proteome-based molecular subtyping and therapeutic target prediction in cervical cancer

Tianying Yang, Lijun Guo, D Y Liu, Keqin Hua et autres

Cervical cancer (CC) represents a leading malignant threat to women’s health globally. Patients with advanced-stage CC frequently encounter limited therapeutic efficacy and prominent drug resistance, highlighting the urgent need for molecular-driven precision treatment strategies. Herein, we developed a proteomics-based molecular classification for …

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CKAP2 promotes cervical cancer progression by modulating the tumor microenvironment via NF-κB signaling: Am J Cancer Res. 2023; 13(6): 2376-2391

Lijun Guo, Chunbo Li, Jingjing Guo, Junjun Qiu et autres

[This corrects the article on p. 2376 in vol. 13, PMID: 37424820.].

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Deciphering the hepatoprotective mechanism of Sarcopyramis nepalensis wall against non-alcoholic fatty liver disease by network pharmacology and experimental validation

Huifang Lai, Chenting Zhu, Xiaofeng Li, Lishan He et autres

Non-alcoholic fatty liver disease (NAFLD) represents a widespread hepatic condition marked by excessive lipid accumulation. Sarcopyramis nepalensis Wall (S. nepalensis), a hepatoprotective traditional Chinese herbal medicine, has unclear pharmacodynamics and mechanisms against NAFLD. This study integrated UHPLC-Q Exactive Orbitrap-HRMS analysis, network pharmacology, …

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Optimization of carbon dioxide insufflation strategies in minimally invasive cardiac surgery: the efficacy of continuous insufflation protocols with left ventricular venting

Zhibin Hu, Wenshuai Mao, Lijun Guo, Zhiwei Liu et autres

OBJECTIVES: Although CO₂ insufflation play an established role in open-heart surgery, its optimal application in minimally invasive cardiac procedures remains unclear. This study systematically compared continuous versus single CO₂ insufflation protocols during minimally invasive modified morrow procedures, and assessed the influence of …

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TCT-107 Angiography-derived fractional flow reserve versus intravascular ultrasound to guide percutaneous coronary intervention according to clinical risk and lesion complexity

Bon-Kwon Koo, Seokhun Yang, Xinyang Hu, Jinlong Zhang et autres

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Causes of In-Hospital Death in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention in Beijing Area

Jing Li, Yinghua Zhang, Yixin Ma, Jinghao Sun et autres

This study aimed to identify causes of in-hospital death in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PPCI) in the Beijing metropolitan area. A total of 56,763 PPCIs were performed at 56 eligible hospitals between January 1, 2010, and …

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Development of a Robust FLASH Research Platform for In Vivo Spinal Cord Study with Image-Guided Dosimetry

Bin Zhou, Lijun Guo, Yi‐Chun Tsai, John W. Wong et autres

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Two-year outcomes of quantitative flow ratio-based physiology-guided percutaneous coronary intervention in patients with low-risk acute coronary syndrome: a prespecified secondary analysis of FAVOR III China

Song Z. Ding, Zien Zhou, Zhiguo Zou, Fuyu Cheng et autres

Background The benefits of physiology-guided management in acute coronary syndrome (ACS) remain inconclusive due to limited evidence. In our FAVOR III China trial, a quantitative flow ratio (QFR)-based physiology-guided strategy versus standard angiography guidance improved the 1-year primary outcome among participants with …

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The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014

Gaocan Ren, Yifei Wang, Yicheng Liu, Hongwei Zhang et autres

BACKGROUND: Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high-density lipoprotein cholesterol (log[TG/HDL-C]), has emerged …

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Insulin resistance related indices are associated with the presence of Cardiorenal syndrome: insights from NHANES 2005-2020

Jinhui Zhang, Gaocan Ren, Zhi Jian Yao, Jiatao Liu et autres

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Angiography-derived fractional flow reserve versus intravascular ultrasound to guide percutaneous coronary intervention in patients with coronary artery disease (FLAVOUR II): a multicentre, randomised, non-inferiority trial

Xinyang Hu, Jinlong Zhang, Seokhun Yang, Jun Jiang et autres

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Cost-effectiveness of angiographic quantitative flow ratio-guided coronary intervention: A multicenter, randomized, sham-controlled trial

Yanyan Zhao, C D Guan, Yang Wang, Zening Jin et autres

BACKGROUND: The FAVOR (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients with Coronary Artery Disease) III China trial demonstrated that percutaneous coronary intervention (PCI) lesion selection using quantitative flow ratio (QFR) measurement, a novel angiography-based approach for …

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