The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014
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BACKGROUND: Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high-density lipoprotein cholesterol (log[TG/HDL-C]), has emerged as a novel biomarker reflecting the balance between proatherogenic and antiatherogenic lipoproteins. Nevertheless, the association between AIP and cognitive function has not been examined in a large cohort. This study examined the relationship between AIP and cognitive performance in a nationally representative cohort of adult Americans. METHODS: A cross-sectional study was conducted using data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). The relationship between AIP and cognitive function was examined using several multivariate regression models with adjustment for arrays of potential confound factors. Fitted smoothed curves and threshold effect analysis were used to characterize possible nonlinear relationships. RESULTS: The study population comprised 995 adults (mean age 63.01 ± 14.93 years; 51.86% female), with 49.65% identifying as non-Hispanic White, 9.15% as Mexican American, and 20.2% as non-Hispanic Black. Higher AIP was associated with greater risk of cognitive impairment. Negative correlations were detected between the AIP and both Animal Fluency Test (AFT) performance (β = -5.54, 95%CI: -9.26, -1.82, p < 0.05) and Digit Symbol Substitution Test (DSST) performance (β = -15.79, 95% CI: -26.32, -5.27, p < 0.05) after adjusting for multiple confounding variables. CONCLUSION: Elevated AIP is associated with cognitive impairment in adult Americans.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014
- Date Crossref
- 01/08/2025
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Xiyuan Hospital pays non établi dans la noticeÉtablissement de santé
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China Academy of Chinese Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Beijing University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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National Clinical Research Center for Digestive Diseases pays non établi dans la noticeÉtablissement de santé
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National Clinical Research Center for Chinese Medicine Cardiology Beijing China pays non établi dans la noticeStructure de recherche
Chinese Academy of Medical Sciences & Peking Union Medical College, Xiyuan Hospital et China Academy of Chinese Medical Sciences, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.