Eva Czirr

Effects of Extracorporeal Blood Flow Rates on Patient Tolerance for LIXELLE® Treatment during Outpatient Hemodialysis

Onkar S. Dhande, Arnaud Teichert, Varshasb Broumand, H. Kakita et autres

INTRODUCTION: Accumulation of β2-microglobulin (B2M) in dialysis patients contributes to several comorbidities of end-stage kidney disease (ESKD). The LIXELLE® device adsorbs B2M from blood using sorbent bead technology. Studies in Japan showed that LIXELLE treatment during hemodialysis (HD) at blood flow rates …

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Supplementary Material for: Effects of extracorporeal blood flow rates on patient tolerance for LIXELLE® treatment during outpatient hemodialysis

Dhande O.S., Arnaud Teichert, V. Broumand, H. Kakita et autres

Introduction: Accumulation of β2-microglobulin (B2M) in dialysis patients contributes to several comorbidities of end stage kidney disease (ESKD). The LIXELLE® device adsorbs B2M from blood using sorbent bead technology. Studies in Japan showed LIXELLE treatment during hemodialysis (HD) at blood flow rates …

Supplementary Material for: Effects of extracorporeal blood flow rates on patient tolerance for LIXELLE® treatment during outpatient hemodialysis

Dhande O.S., Arnaud Teichert, V. Broumand, H. Kakita et autres

Introduction: Accumulation of β2-microglobulin (B2M) in dialysis patients contributes to several comorbidities of end stage kidney disease (ESKD). The LIXELLE® device adsorbs B2M from blood using sorbent bead technology. Studies in Japan showed LIXELLE treatment during hemodialysis (HD) at blood flow rates …

Supplementary Material for: Effects of extracorporeal blood flow rates on patient tolerance for LIXELLE® treatment during outpatient hemodialysis

Dhande O.S., Arnaud Teichert, V. Broumand, H. Kakita et autres

Introduction: Accumulation of β2-microglobulin (B2M) in dialysis patients contributes to several comorbidities of end stage kidney disease (ESKD). The LIXELLE® device adsorbs B2M from blood using sorbent bead technology. Studies in Japan showed LIXELLE treatment during hemodialysis (HD) at blood flow rates …

Supplementary Material for: Effects of extracorporeal blood flow rates on patient tolerance for LIXELLE® treatment during outpatient hemodialysis

Dhande O.S., Arnaud Teichert, V. Broumand, H. Kakita et autres

Introduction: Accumulation of β2-microglobulin (B2M) in dialysis patients contributes to several comorbidities of end stage kidney disease (ESKD). The LIXELLE® device adsorbs B2M from blood using sorbent bead technology. Studies in Japan showed LIXELLE treatment during hemodialysis (HD) at blood flow rates …

Leukotriene A4 hydrolase inhibition improves age-related cognitive decline via modulation of synaptic function

Julia M. Adams, Sanket V. Rege, Angela T. Liu, Ninh V. Vu et autres

Leukotrienes, a class of inflammatory bioactive lipids, are well studied in the periphery, but less is known of their importance in the brain. We identified that the enzyme leukotriene A4 hydrolase (LTA4H) is expressed in healthy mouse neurons, and inhibition of LTA4H …

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Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging

Rachel A. Britton, Tristan Wasley, Reema Harish, Charles Holz et autres

Abstract Peripheral administration of tissue inhibitor of metalloproteinases 2 (TIMP2), a protein inhibitor of matrix metalloproteinases (MMPs), has previously been shown to have beneficial effects on cognition and neurons in aged mice. Here, to better understand the potential of recombinant TIMP2 proteins, …

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Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice

Rachel A. Britton, Angela T. Liu, Sanket V. Rege, Julia M. Adams et autres

INTRODUCTION: Increasing age is the number one risk factor for developing cognitive decline and neurodegenerative disease. Aged humans and mice exhibit numerous molecular changes that contribute to a decline in cognitive function and increased risk of developing age-associated diseases. Here, we characterize …

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Author response for "Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice"

Rachel A. Britton, Angela T. Liu, Sanket V. Rege, Julia M. Adams et autres

Beneficial Effects of a Plasma Fraction on Inflammation and Synaptic Deficits for Age-Related Cognitive Disorders

Ian Gallager, Jasmine Torres, Raniel Alcantara‐Lee, Chirag Thadani et autres

Abstract The process of aging is multifactorial, and therefore single agent interventions would be unlikely to attenuate the myriad pathologies associated with advancing age. Plasma contains many beneficial factors which have been shown in animal models to ameliorate multiple age-related deficits across …

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A Randomized, Double-Blind, Phase 2 Study to Evaluate the Tolerability, Feasibility, and Efficacy of AKST1210 in Patients on Hemodialysis with ESRD and Cognitive Impairment

Seema Garg, Eva Czirr, Katie Koborsi, Anthony Kalife et autres

Background: Cognitive impairment is frequently observed in many end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Since this protein is not effectively cleared with standard HD, beta-2 microglobulin (b2M) is highly elevated in ESRD patients and data in mice has shown that …

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The Plasma Factor Beta-2 Microglobulin Drives Cognitive Impairment in ESRD

Eva Czirr, David Le, Cindy F. Yang, Shreya Chand et autres

Background: Our goal is to decode changes in the plasma proteome in age and disease to identify novel therapeutic targets. We and others have shown that administration of aged human plasma in young immunodeficient mice results in impaired neurogenesis and cognition. We …

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