Yusuke Okabayashi

Does pregnancy modify disease activity in C3 glomerulopathy?

Yuya Yamaguchi, Yusuke Okabayashi, Masahiro Okabe, Nobuo Tsuboi et autres

jp (code pays fourni par la source)

Single-Nephron Dynamics Across Chronic Kidney Disease Stages in Overt Diabetic Nephropathy

Akane Miura, Masahiro Okabe, Yusuke Okabayashi, Takaya Sasaki et autres

Abstract Background Single-nephron glomerular filtration rate (GFR) represents a nephron-level functional index that may reveal key pathophysiological mechanisms driving progression in patients with diabetic nephropathy. However, its clinical relevance remains incompletely understood. This cross-sectional study assessed single-nephron estimated GFR (eGFR) across different …

jp (code pays fourni par la source)

Integrating nephron number into risk stratification for IgA nephropathy

Yuya Yamaguchi, Takaya Sasaki, Nobuo Tsuboi, Hirokazu Marumoto et autres

jp, us, au (code pays fourni par la source)

WCN26-4629 Variability in Glomerular Area and Adverse Kidney Outcomes in IgA Nephropathy

Leo Nozaki, Takaya Sasaki, Nobuo Tsuboi, Hirokazu Marumoto et autres

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and a leading cause of chronic kidney disease (CKD). Histopathological systems such as the Oxford classification assess lesion severity but mainly reflect localized injury patterns, potentially missing broader structural heterogeneity or the …

jp (code pays fourni par la source)

WCN26-1195 Variability in the estimated glomerular filtration rate and adverse kidney outcomes in IgA nephropathy

Takaya Sasaki, Hirokazu Marumoto, Yusuke Okabayashi, Kotaro Haruhara et autres

jp (code pays fourni par la source)

WCN26-7725 Prognostic significance of nephron number deficit relative to age in IgA nephropathy

Hirokazu Marumoto, Nobuo Tsuboi, Takaya Sasaki, Yusuke Okabayashi et autres

WCN26-4289 CLINICAL AND PATHOLOGICAL FEATURES OF IGA NEPHROPATHY ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE: A COMPARATIVE STUDY WITH EMPHASIS ON CROHN'S DISEASE

Akihiro Shimizu, Nobuo Tsuboi, Saeko Hatanaka, Shohei Fukunaga et autres

The association between IgA nephropathy (IgAN) and inflammatory bowel disease (IBD) has gained attention, yet the clinical and pathological characteristics of IgAN in patients with ulcerative colitis (UC) or Crohn's disease (CD) remain poorly defined. This study aimed to compare the clinicopathological …

jp (code pays fourni par la source)

WCN26-6817 PROGNOSTIC VALUE OF ESTIMATED FUNCTIONAL NEPHRON NUMBER AT DIAGNOSIS IN MEMBRANOUS NEPHROPATHY: A LONGITUDINAL COHORT STUDY

Yusuke Okabayashi, Nobuo Tsuboi, Aoi Miyashita, A. Watanabe et autres

Membranous nephropathy (MN) exhibits relatively uniform glomerular pathology, whereas clinical courses are heterogeneous. Anti-PLA2R antibody positivity and clinical features such as male sex, older age, and heavy proteinuria at diagnosis have been linked to prognosis, and electron microscopy (EM) stage is also …

jp (code pays fourni par la source)

WCN26-6728 Proximal Tubular Hypertrophy as an Independent Prognostic Marker in Overt Diabetic Nephropathy: A Retrospective Biopsy-Based Study

Akane Miura, Masahiro Okabe, Takaya Sasaki, Yusuke Okabayashi et autres

Although glomerular pathology is a defining feature of diabetic nephropathy (DN), tubular alterations, particularly proximal tubular hypertrophy, have been increasingly recognized as contributors to disease progression. This study aimed to determine whether proximal tubular hypertrophy is independently associated with adverse kidney outcomes …

jp (code pays fourni par la source)

Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK/STAT signaling

Abhijit S. Naik, FADHL ALAKWAA, Viji Nair, Phillip J. McCown et autres

BACKGROUNDYouth with type 2 diabetes (T2D) and severe obesity face high risk of diabetic kidney disease, which metabolic bariatric surgery (MBS) can mitigate. This study explores structural and molecular changes in kidneys after vertical sleeve gastrectomy (VSG), a form of MBS.METHODSWe performed …

us, it, th, nl, jp, de, dk (code pays fourni par la source)

Hypertension and age‐related focal global glomerulosclerosis are associated with biomarkers for cellular senescence

Michael D. Hughson, Alaa Abbas Ali, Yusuke Okabayashi, Victor G. Puelles et autres

Arterionephrosclerosis is characterized by focal global glomerulosclerosis (FGGS), which is a constant feature of aging and hypertension. FGGS begins as normal-appearing glomeruli that undergo tuft contraction (TC) and progress to global glomerulosclerosis (GGS). Kidney tissue from 26 hypertensive and 25 age-matched non-hypertensive …

us, iq, jp, de, dk, au (code pays fourni par la source)

The Association between Low-Grade Proteinuria and Adverse Kidney Outcomes in IgA Nephropathy

Yuya Yamaguchi, Takaaki Kosugi, Takaya Sasaki, Kotaro Haruhara et autres

KEY POINTS: Systematic review/meta-analysis of 23 studies (15,289 patients) quantified prognostic effect of low-grade proteinuria in IgA nephropathy. Low-grade proteinuria (0.5-1.0 g/d) linked to higher kidney risk (hazard ratio, 1.73-2.87) and faster eGFR decline (-1.02 ml/min per year). Long-term suppression below 0.5 …

jp, au (code pays fourni par la source)