Renza Roncarati

Baculovirus Actin Rearrangement-Inducing Factor 1 Can Remodel the Mammalian Actin Cytoskeleton

Anika Steffen, Björn Reusch, Nadine Gruteser, Daniela Mainz et autres

multiple nucleopolyhedrovirus (AcMNPV) is known for intervening with the regulation of the host actin cytoskeleton in a wide manner throughout the infection cycle. The actin rearrangement-inducing factor 1 (Arif-1) is a viral protein that causes actin rearrangement during the early phase of …

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Baculovirus Actin Rearrangement-Inducing Factor 1 Can Remodel the Mammalian Actin Cytoskeleton

Anika Steffen, Björn Reusch, Nadine Gruteser, Daniela Mainz et autres

The actin rearrangement-inducing factor 1 (Arif-1) of Autographa californicamultiple nucleopolyhedrovirus (AcMNPV) is an early viral protein that manipulates theactin cytoskeleton of host insect cells. Arif-1 is conserved among alphabaculoviruses andis responsible for the accumulation of F-actin at the plasma membrane during the …

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Three dimensional drift control at nano-scale in single molecule localization microscopy

Xiaoming Fan, Thomas Gensch, Georg Büldt, Yuanheng Zhang et autres

Super-resolution imaging based on single molecule localization of cellular structures on nanometer scale requires to record a series of wide-field or TIRF images resulting in a considerable recording time (typically of minutes). Therefore, sample drift becomes a critical problem and will lower …

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Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) – Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer

Achim Wöckel, Jasmin Festl, Tanja Nadine Stüber, Katharina Brust et autres

Abstract Purpose The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. Method The process …

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Interdisziplinäre Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms : Leitlinie der DGGG und DKG (S3-Level, AWMF-Registernummer 032/045OL, Dezember 2017) – Teil 1 mit Empfehlungen zur Früherkennung, Diagnostik und Nachsorge des Mammakarzinoms

Achim Wöckel, Jasmin Festl, Tanja Nadine Stüber, Katharina Brust et autres

Ziele: Das Ziel dieser offiziellen Leitlinie, die von der Deutschen Gesellschaft fur Gynakologie und Geburtshilfe (DGGG) und der Deutschen Krebsgesellschaft (DKG) publiziert und koordiniert wurde, ist es, die Fruherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms zu optimieren. Methoden: Der Aktualisierungsprozess der S3-Leitlinie …

Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) – Part 1 with Recommendations for the Screening, Diagnosis and Therapy of Breast Cancer

Achim Wöckel, Jasmin Festl, Tanja Nadine Stüber, Katharina Brust et autres

Abstract Purpose The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. Methods The process …

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Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction

Sara Iozzi, Rosaria Remelli, Barbara Lelli, Daniela Diamanti et autres

Background. DKK1 antagonizes canonical Wnt signalling through high-affinity binding to LRP5/6, an essential component of the Wnt receptor complex responsible for mediating downstream canonical Wnt signalling. DKK1 overexpression is known for its pathological implications in osteoporosis, cancer, and neurodegeneration, suggesting the interaction …

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Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625

Karen L. Marquis, Thomas A. Comery, Flora Jow, Rachel L. Navarra et autres

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VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin

Lara Rossini, Yuichi Hashimoto, Hiroaki Suzuki, Megumi Kurita et autres

Humanin (HN) is a 24‐residue peptide displaying a protective activity in vitro against a range of cytotoxic and neurotoxic insults, as well as mediating in vivo amelioration of Alzheimer disease (AD)‐related memory impairment in experimental models. Published evidence suggests that the mechanisms …

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S.20.04 Alpha7 signalling pathways and their relevance to cognition

Renza Roncarati

Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)

Chiara Ghiron, Simon N. Haydar, Suzan Aschmies, Hendrick Bothmann et autres

Alpha-7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series of novel, potent small molecule agonists (4-18) of the alpha7 nAChR deriving from our continuing efforts in the areas of Alzheimer's …

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Screening Technologies for Ion Channel Drug Discovery

Georg C. Terstappen, Renza Roncarati, John Dunlop, Ravikumar Peri

For every movement, heartbeat and thought, ion channels need to open and close. It is therefore not surprising that their malfunctioning leads to serious diseases. Currently, only approximately 10% of drugs, with a market value in excess of US$10 billion, act on …

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