Martin Post

Supplementary Material for Lipidomes of placenta-derived extracellular vesicles reveal disrupted metabolic adaptation in type 1 diabetes

Miira M. Klemetti, Jiayi Li, Sruthi Alahari, Ante B. V. Pettersson et autres

Context: Placental metabolic adaptation is dynamically orchestrated across gestation to support fetal development, yet how this process is disrupted in type 1 diabetes (T1D) and contributes to altered fetal metabolic outcomes remains unclear. Small extracellular vesicles (sEVs) may provide a minimally invasive …

Supplementary Material for Lipidomes of placenta-derived extracellular vesicles reveal disrupted metabolic adaptation in type 1 diabetes

Miira M. Klemetti, Jiayi Li, Sruthi Alahari, Ante B. V. Pettersson et autres

Context: Placental metabolic adaptation is dynamically orchestrated across gestation to support fetal development, yet how this process is disrupted in type 1 diabetes (T1D) and contributes to altered fetal metabolic outcomes remains unclear. Small extracellular vesicles (sEVs) may provide a minimally invasive …

Supplementary Material for Lipidomes of placenta-derived extracellular vesicles reveal disrupted metabolic adaptation in type 1 diabetes

Miira M. Klemetti, Jiayi Li, Ante B. V. Pettersson, Sruthi Alahari et autres

Context: Placental metabolic adaptation is dynamically orchestrated across gestation to support fetal development, yet how this process is disrupted in type 1 diabetes (T1D) and contributes to altered fetal metabolic outcomes remains unclear. Small extracellular vesicles (sEVs) may provide a minimally invasive …

Placental small extracellular vesicles and cardiac mitochondrial dynamics in preeclampsia

Sruthi Alahari, Julien Sallais, Chanho Park, Mia Feldman et autres

Abstract Preeclampsia is a hypertensive disorder of pregnancy that confers a markedly increased risk of maternal cardiovascular disease, yet the mechanisms linking placental pathology to maternal cardiac dysfunction remain poorly understood. Placental hypoxia is a central feature of early-onset preeclampsia (E-PE) and …

ca (code pays fourni par la source)

Intrauterine oxygen milieu governs placental sphingolipid metabolism

Julien Sallais, Martin Post, Isabella Caniggia

Early placentation relies on temporal changes in intrauterine oxygen tension that regulate trophoblast differentiation events. Studies have highlighted the contribution of bioactive sphingolipids to the pathogenesis of placental disorders, characterized by hypoxia. However, it is unknown whether placental sphingolipid metabolism changes during …

ca (code pays fourni par la source)

Reply to Liu: Alveolar Collapse in Acute Respiratory Distress Syndrome Causes Severe Lung Damage, but What About Liquid Resuscitation?

Mayson Laércio de Araújo Sousa, Bhushan H. Katira, Sheena Bouch, Vanessa Hsing et autres

ca, br, us (code pays fourni par la source)

Is There an Optimal PEEP for Pulmonary Hemodynamics in Acute Injured Lungs?

Mayson Laércio de Araújo Sousa, Luca Salvatore Menga, Annia Fleur Schreiber, Mattia Docci et autres

Abstract RATIONALE: Several methods exist for setting positive end-expiratory pressure (PEEP), often leading to different PEEP levels. These variations may not only influence respiratory mechanics but also affect other critical factors, such as pulmonary vascular responses. OBJECTIVES: The main goal of this …

ca, us, se, cl, br (code pays fourni par la source)

Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury

Mayson Laércio de Araújo Sousa, Luca Salvatore Menga, Annia Fleur Schreiber, Mattia Docci et autres

Abstract Rationale There are several approaches to select the optimal positive end-expiratory pressure (PEEP), resulting in different PEEP levels. The impact of different PEEP settings may extend beyond respiratory mechanics, affecting pulmonary hemodynamics. Objectives To compare PEEP levels obtained with three titration …

ca, us, se, cl, br (code pays fourni par la source)

Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia

Chanho Park, Sruthi Alahari, Jonathan Ausman, Ruizhe Liu et autres

BACKGROUND: Iron is an essential micronutrient for cell survival and growth; however, excess of this metal drives ferroptosis. Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which …

ca (code pays fourni par la source)

Intermittent Phrenic Nerve Stimulation May Prevent Atelectasis and Ventilator-induced Diaphragm Dysfunction

Mayson Laércio de Araújo Sousa, L. Felipe Damiani, Sebastián Dubó, Annia Fleur Schreiber et autres

ca, br, cl, fr, us (code pays fourni par la source)

Influence of mesenchymal and biophysical components on distal lung organoid differentiation

Olivia Goltsis, Claudia Bilodeau, Jinxia Wang, Daochun Luo et autres

BACKGROUND: Chronic lung disease of prematurity, called bronchopulmonary dysplasia (BPD), lacks effective therapies, stressing the need for preclinical testing systems that reflect human pathology for identifying causal pathways and testing novel compounds. Alveolar organoids derived from human pluripotent stem cells (hPSC) are …

ca, us (code pays fourni par la source)

Heightened ferroptosis in preeclampsia leads to endothelial damage via placental small extracellular vesicles enriched in lipid hydroperoxides

Sruthi Alahari, Chanho Park, Martin Post, Isabella Caniggia

ca (code pays fourni par la source)