Jonathan Ausman

Recurrent pustular psoriasis of pregnancy and postpartum flare

Emily Richmond, Jessica MacIntyre, Lourdes Ramírez Hobak, Jonathan Ausman

Key points • Pustular psoriasis of pregnancy (PPP) is a rare dermatosis of pregnancy that can lead to life-threatening maternal and fetal complications.• Risk of recurrence in subsequent pregnancies is high, with earlier presentation and symptoms found to be more severe.• Treatments …

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Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia

Chanho Park, Sruthi Alahari, Jonathan Ausman, Ruizhe Liu et autres

BACKGROUND: Iron is an essential micronutrient for cell survival and growth; however, excess of this metal drives ferroptosis. Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which …

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Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia

Sruthi Alahari, Jonathan Ausman, Tyler R. Porter, Chanho Park et autres

Preeclampsia (PE) is a major obstetric complication that is challenging to predict. Currently, there are limited tools to assess placental health/function in crucial gestational periods for diagnosis and early prediction. The glycoprotein fibronectin (FN) is augmented in PE placentae, and associated with …

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Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis

Taylor Gillmore, Abby Farrell, Sruthi Alahari, Julien Sallais et autres

Dynamic changes in physiologic oxygen are required for proper placenta development; yet, when low-oxygen levels persist, placental development is halted, culminating in preeclampsia (PE), a serious complication of pregnancy. Considering mitochondria's function is intimately linked to oxygen changes, we investigated the impact …

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Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction

Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman et autres

Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown. Here we report that lysosome formation is markedly increased in trophoblast cells of early-onset …

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Alterations in Mitochondrial Dynamics in Placentae From Women Who Smoke During Pregnancy

Jonathan Ausman, K.Pat Bell, Alex Post, Nichole Pederson et autres

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Ceramide-induced BOK promotes mitochondrial fission in preeclampsia

Jonathan Ausman, Joélcio Francisco Abbade, Leonardo Ermini, Abby Farrell et autres

Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in removal of non-functional organelles. Changes in mitochondrial dynamics typify several human diseases. However, the contribution of mitochondrial dynamics to …

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A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia

Leonardo Ermini, Jonathan Ausman, Megan Melland‐Smith, Behzad Yeganeh et autres

Preeclampsia (PE), an hypertensive disorder of pregnancy, exhibits increased circulating levels of a short form of the auxillary TGF-beta (TGFB) receptor endoglin (sENG). Until now, its release and functionality in PE remains poorly understood. Here we show that ENG selectively interacts with …

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Regulation of Mitochondrial Fission by Ceramide-induced Bcl-2-related Ovarian Killer in Preeclampsia

Jonathan Ausman

Mitochondrial fission (MF) is regulated by the dynamin-related protein 1 (DRP1), and its excess is implicated in a number of human diseases. Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with elevated placental ceramide (CER), a bioactive sphingolipid implicated in cell …

Secretion of sFLT1 and sENG into the maternal circulation

Leonardo Ermini, Jonathan Ausman, Michael L. Litvack, Michelle Letarte et autres

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Social Factors Influencing Career Choice in a Medical School in the United Arab Emirates

Jonathan Ausman, Anas Javed, Shuja Ahmed, Mohammad Abdul Samad et autres

Objective: The goal of this research was to identify familial and nonfamilial social factors influencing post-secondary students' choices of career in medicine.Method: The comparative study was conducted in Ajman, among medical students in the beginning three years, and nonmedical students at the …

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