Grantham C. Peltier

In Vitro Evaluation of the Co‐Administration of Canine Blood Products and Drugs Used in Critical Illness

Gonzalo Rivas, Thomas H. Edwards, Grantham C. Peltier, Hoa Mai Nguyen et autres

OBJECTIVE: To analyze the effects of co-administering various drugs with canine whole blood (WB), canine fresh frozen plasma (FFP), or canine freeze-dried plasma (FDP), and determine whether alterations to the blood constituents or drugs exist within the admixture. DESIGN: In vitro experimental …

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Assessing direct transfusion feasibility with syringe‐based collection of whole blood from universal donors

Chet Voelker, Grantham C. Peltier, Nichelle Crenshaw, Michael A. Meledeo et autres

BACKGROUND: The anticipated multidomain operations of future battlefields necessitates minimalistic medical strategies for treatment of combat wounded. Direct transfusion, involving the administration of blood directly from a donor to a recipient, may be a solution for treating hemorrhagic shock patients in an …

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In vitro evaluation of hyperosmotic canine plasma suitable for infusion

Thomas H. Edwards, Michael A. Meledeo, Grantham C. Peltier, Alice F. Henderson et autres

OBJECTIVE: To determine the characteristics of canine freeze-dried plasma (cFDP) as it is serially diluted with sterile water. DESIGN: In vitro experimental study. SETTING: Government blood and coagulation research laboratory. ANIMALS: cFDP from a commercial manufacturer. INTERVENTIONS: Ten units of cFDP were …

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The impact of delivery by a fixed-wing, sling-launched unmanned aerial vehicle on the hematologic function of whole blood

Grantham C. Peltier, Michael A. Meledeo

BACKGROUND: Unmanned aerial vehicles (UAVs) have been shown to shorten delivery times of medical products in health care, providing a potential answer to the question of prehospital resuscitation where blood and blood products are not readily available. While the capabilities and efficiencies …

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Hemoglobin-Based Oxygen Carrier for the Reconstitution of Canine Freeze-Dried Plasma in an In Vitro Model of Resuscitation

Thomas H. Edwards, Michael A. Meledeo, Grantham C. Peltier, Alice F. Henderson et autres

Military working dogs (MWDs) are force multipliers that are at risk for severe trauma when employed on the battlefield. When in severe hemorrhagic shock, MWDs require both oxygen- carrying capacity and replacement of vascular volume and coagulation factors. The objective of this …

Trauma Biomarkers in Plasma during the First 24 Hours

Michael A. Meledeo, Grantham C. Peltier, Colby S. McIntosh, Nicholas Mucha et autres

Abstract Background Efforts to reduce prehospital mortality are limited by the available tools. Transfusion resources are limited, and early identification of coagulopathy is difficult. The future ability to optimize care will be dependent on knowing which resources are best suited for specific …

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Coagulation function of never frozen liquid plasma stored for 40 days

Michael A. Meledeo, Grantham C. Peltier, Colby S. McIntosh, James A. Bynum et autres

BACKGROUND: Never frozen liquid plasma (LP) has limited shelf life versus fresh frozen plasma (FFP) or plasma frozen within 24 h (PF24). Previous studies showed decreasing factor activities after Day (D)14 in thawed FFP but no differences between LP and FFP until …

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Effects of refrigerated storage on hemostatic stability of four canine plasma products

Thomas H. Edwards, Michael A. Meledeo, Grantham C. Peltier, Daikor D. Ruiz et autres

Abstract OBJECTIVE To assess clotting times, coagulation factor activities, sterility, and thromboelastographic parameters of liquid plasma (LP), thawed fresh frozen plasma (FFP-T), and 2 novel formulations of freeze-dried plasma (FDP) stored refrigerated over 35 days. SAMPLE 6 units of canine LP and …

TEG PlateletMapping assay results may be misleading in the presence of cold stored platelets

Thomas Scorer, Lucy Fitzgibbon, Riyaad Aungraheeta, Umang Sharma et autres

BACKGROUND Viscoelastic tests (VETs) are used widely to monitor hemostasis in settings such as cardiac surgery. There has also been renewed interest in cold stored platelets (CSPs) to manage bleeding in this setting. CSPs are reported to have altered hemostatic properties compared …

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Field‐expedient thawing of fresh‐frozen plasma

Michael A. Meledeo, Grantham C. Peltier, Colby S. McIntosh, Jason B. Corley et autres

INTRODUCTION: Frozen plasma is superior to crystalloids for hemorrhage resuscitation but remains logistically challenging in austere environments because of specialized clinical equipment for on-demand thawing. This research examines some ad hoc thawing techniques that have been implemented by military medical personnel. METHODS: …

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Effect of Extended Platelet Storage on Platelet Metabolism and Clot Retraction

Prajeeda M. Nair, Michael A. Meledeo, Xiaowu Wu, Grantham C. Peltier et autres

Background: Platelet (PLT) hemostatic responses are heavily dependent on PLT bioenergetics which drives the generation of PLT contractile forces and contribute to mechanical hemostasis. Although effective clot retraction (CR) requires PLT adhesion, aggregation and formation of strong clots, CR remains an understudied …

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Fibrinogen-Mediated Platelet Microaggregate Formation in Stored Whole Blood

Michael A. Meledeo, Grantham C. Peltier, James A. Bynum

Introduction: Whole blood is regaining popularity in resuscitation after hemorrhage. The platelet storage lesion that has been observed in apheresis platelets also exists in whole blood, where platelet count and aggregation response decline rapidly after collection and during storage in the blood …

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