Lucia Verrillo

Additional file 1 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 1: Supplementary Methods: 1. Microwave-assisted solid phase peptide synthesis of fАβ. 2. Preparation of fluorescent Aβ fibrils. 3. Fluorescence labeled fAβ phagocytosis assay. 4. Immunofluorescence analysis. 5. Morphological analysis of primary microglia. 6. Neuron-microglia cocultures. 7. Time lapse imaging.

it, fr (code pays fourni par la source)

Additional file 1 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 1: Supplementary Methods: 1. Microwave-assisted solid phase peptide synthesis of fАβ. 2. Preparation of fluorescent Aβ fibrils. 3. Fluorescence labeled fAβ phagocytosis assay. 4. Immunofluorescence analysis. 5. Morphological analysis of primary microglia. 6. Neuron-microglia cocultures. 7. Time lapse imaging.

it, fr (code pays fourni par la source)

Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Abstract Background Microglial dysfunction has emerged as a critical factor in the Alzheimer’s Disease (AD), with innate immune dysregulation driving pathological progression. This growing understanding has shifted attention toward the therapeutic modulation of glial response as a means to restore immune balance …

it, fr (code pays fourni par la source)

Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Abstract Background Microglial dysfunction has emerged as a critical factor in the Alzheimer’s Disease (AD), with innate immune dysregulation driving pathological progression. This growing understanding has shifted attention toward the therapeutic modulation of glial response as a means to restore immune balance …

it, fr (code pays fourni par la source)

Additional file 2 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 2: Supplementary Data: Supplementary Figure 1: SULF A did not induce significative cytokine production by primary murine microglia. Supplementary Figure 2: SULF A-treated cells did not exhibit increased uptake of these non-opsonic targets. Supplementary Figure 3: SULF A enhances microglial …

it, fr (code pays fourni par la source)

Additional file 2 of Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

Supplementary Material 2: Supplementary Data: Supplementary Figure 1: SULF A did not induce significative cytokine production by primary murine microglia. Supplementary Figure 2: SULF A-treated cells did not exhibit increased uptake of these non-opsonic targets. Supplementary Figure 3: SULF A enhances microglial …

it, fr (code pays fourni par la source)

Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease

Carmela Gallo, Lucia Verrillo, Emiliano Manzo, Emma Cauzzi et autres

BACKGROUND: Microglial dysfunction has emerged as a critical factor in the Alzheimer’s Disease (AD), with innate immune dysregulation driving pathological progression. This growing understanding has shifted attention toward the therapeutic modulation of glial response as a means to restore immune balance and …

it, fr (code pays fourni par la source)

Innovative Application of a Multifunctional Sucrose–Gelatin Hydrogel Matrix in Desorption Electrospray Ionization-Mass Spectrometry Imaging

Marcello Ziaco, Giovanni Andrea Vitale, Giusi Barra, Brenda Marfella et autres

Desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) is among the most powerful techniques for visualizing the spatial distribution of small organic molecules, particularly lipids, on tissue surfaces. Conventional DESI-MSI analysis typically involves sectioning fresh-frozen tissues or, less commonly, embedding samples in matrices specifically …

it (code pays fourni par la source)

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction

Denise Drongitis, Lucia Verrillo, Alberto de Bellis, Maria Giuseppina Miano

Modulation of RNA and protein expression to restore or normalize neuronal function has emerged as a powerful therapeutic strategy for neurodevelopmental disorders (NDDs) tailoring individual genetic mutations causing intellectual disability (ID), or autism spectrum disorder (ASD), or developmental epileptic encephalopathy (DEE). In …

it (code pays fourni par la source)

Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1

Lucia Verrillo, Fabio Arturo Iannotti, Denise Drongitis, Katiuscia Martinello et autres

Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, …

it, ca (code pays fourni par la source)

Suberoylanilide Hydroxamic Acid (SAHA) Is a Driver Molecule of Neuroplasticity: Implication for Neurological Diseases

Lucia Verrillo, Rosita Di Palma, Alberto de Bellis, Denise Drongitis et autres

Neuroplasticity is a crucial property of the central nervous system to change its activity in response to intrinsic or extrinsic stimuli. This is mainly achieved through the promotion of changes in the epigenome. One of the epi-drivers priming this process is suberoylanilide …

it (code pays fourni par la source)

Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants

Emanuela Leonardi, Maria Cristina Aspromonte, Denise Drongitis, Elisa Bettella et autres

it, gb, pl (code pays fourni par la source)