Indresh Kaur

Role of BK Virus CTLs in the Treatment of BK Virus–Associated Nephropathy in Kidney‐Transplant and Hematopoietic Cell Transplant Recipients

Amanda Leigh Olson, Ye Ethan Li, Rafet Başar, Pinaki Banerjee et autres

BACKGROUND: BK virus infection is a marker of poor immune recovery, especially after kidney or allogeneic cell transplantation. Because of the challenges associated with BK virus infection and the lack of effective treatments, there is a growing interest in novel approaches, such …

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Ex vivo mesenchymal progenitor cell-based cord blood cell expansion and exofucosylation to enhance transplant engraftment

Portia Smallbone, Mayela Carolina Mendt, Robert Sackstein, Mark R. Tanner et autres

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Ex Vivo Expanded Cord Blood Natural Killer Cells Combined with Rituximab and High-Dose Chemotherapy and Autologous Stem Cell Transplantation for B Cell Non-Hodgkin Lymphoma

Yago L. Nieto, Pinaki Prosad Banerjee, Indresh Kaur, Kun Hee Kim et autres

Relapse is the major cause of failure of high-dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) for B cell non-Hodgkin lymphomas (B-NHL). Improvement strategies include use in combination with effective immunotherapies. We hypothesized that the combination of rituximab/HDC/ASCT with expanded cord …

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Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation

Amanda Leigh Olson, Ruitao Lin, David Marín, Hind Rafei et autres

PURPOSE: BK virus-associated hemorrhagic cystitis (BKV-HC) is a common complication of allogenic hematopoietic stem cell transplantation (AHSCT), particularly in recipients of alternative donor transplants, which are being performed in increasing numbers. BKV-HC typically results in painful hematuria, urinary obstruction, and renal dysfunction, …

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Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu, David Marín, Pinaki Prosad Banerjee, Homer A. Macapinlac et autres

BACKGROUND: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown remarkable clinical efficacy in B-cell cancers. However, CAR T cells can induce substantial toxic effects, and the manufacture of the cells is complex. Natural killer (NK) cells that have been modified to …

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Evidence for the role of histaminergic pathways in neuroprotective mechanism of ischemic postconditioning in mice

Indresh Kaur, Amit Kumar, Amteshwar Singh Jaggi, Nirmal Singh

The present study has been designed to investigate the possible role of histaminergic pathway in neuroprotective mechanism of ischemic postconditioning (iPoCo). Bilateral carotid artery occlusion (BCAO) for 12 min followed by reperfusion for 24 h was employed to produce I/R-induced cerebral injury …

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A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy

Abdullah Alsuliman, Stanley H. Appel, David R. Beers, Rafet Başar et autres

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Low rate of infusional toxicity after expanded cord blood transplantation

Adham Sean Bear, Patrick J. Hanley, Doyle Bosque, Carolina Colli Cruz et autres

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DCVax®- DIRECT: autologous activated dendritic cells for image guided intra-tumoral vaccination in patients with solid tumors - a phase I/II clinical trial in progress

Vivek Subbiah, RAVI K. MURTHY, Chitra M. Hosing, Indresh Kaur et autres

Meeting abstracts Dendritic cells (DC) are acknowledged to be quintessential in the armamentarium to mount anti-tumor immune responses and have been utilized in varying capacities for cancer immunotherapy. Recent advancements & lessons leant from prior DC therapies have revealed that major barriers

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