Dalileh Nabi

Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes

Dalileh Nabi, Davide Bosi, Neha Gupta, Nidhi A. Thaker et autres

In brief: Oocyte quality remains the most important and unsolved issue in reproduction. Our data show that multidrug resistance transporters and oocyte mitochondria are involved in determining oocyte quality in a mouse model. Abstract: Multidrug resistance transporter-1 (MDR-1) is a transmembrane ATP-dependent …

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P-689 Mutated MDR-1 impairs chromosome alignment and reduces oocyte quality

Davide Bosi, Dalileh Nabi, Lynae M. Brayboy

Abstract Study question With this study we aim to assess the link between oocyte mitochondrial physiology and spindle formation with respect to Multidrug Resistance transporter 1 (MDR-1) function. Summary answer Our most recent data suggest that oocyte quality is compromised in young …

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The Role of T Cells in Ovarian Physiology and Infertility

Laura O. Knapik, Shubangi Paresh, Dalileh Nabi, Lynae M. Brayboy

Infertility affects one in six couples worldwide, with more than 48 million couples affected internationally. The prevalence of infertility is increasing which is thought to be attributed to delayed child-bearing due to socioeconomic factors. Since women are more prone to autoimmune diseases, …

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CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes

Dalileh Nabi, Hauke Drechsler, Johannes Pschirer, Franz Korn et autres

Abstract Proper chromosome segregation is essential to avoid aneuploidy, yet this process fails with increasing age in mammalian oocytes. Here we report a role for the scarcely described protein CENP-V in oocyte spindle formation and chromosome segregation. We show that depending on …

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Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood

Pia Michler, Anne Schedel, Martha Witschas, Ulrike Anne Friedrich et autres

While the shelterin complex guards and coordinates the mechanism of telomere regulation, deregulation of this process is tightly linked to malignant transformation and cancer. Here, we present the novel finding of a germline stop-gain variant (p.Q199*) in the shelterin complex gene POT1, …

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The Spindle Assembly Checkpoint Functions during Early Development in Non-Chordate Embryos

Janet M. Chenevert, Marianne Roca, Lydia Besnardeau, Antonella Ruggiero et autres

In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. …

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Bisphenols disrupt differentiation of the pigmented cells during larval brain formation in the ascidian

Isa D. L. Gomes, Ievgeniia Gazo, Dalileh Nabi, Lydia Besnardeau et autres

fr, cz (code pays fourni par la source)

The spindle assembly checkpoint functions during early development in non-chordate embryos

Janet M. Chenevert, Marianne Roca, Lydia Besnardeau, Antonella Ruggiero et autres

In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation. This control mechanism monitors proper attachment of chromosomes to spindle microtubules and delays mitotic progression if connections are erroneous or absent. The SAC operates in all eukaryotic cells tested so …

fr (code pays fourni par la source)