Huichun Li

Early-warnings of critical transitions emerging from network hierarchies

Huichun Li, Zhenghu Zu, Xue Zhang, Chengli Zhao et autres

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Optimization of infectious disease intervention measures using reinforcement learning with UK COVID-19 epidemic data

Baida Zhang, Yakai Chen, Huichun Li, Zhenghu Zu

Globally, the outbreaks of infectious diseases have exerted an extremely profound and severe influence on health security and the economy. During the critical phases of epidemics, devising effective intervention measures poses a significant challenge to both the academic and practical arenas. There …

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Efficient reporting delay calibration in spatial metapopulation models for reconstructing cross-regional epidemic dynamics

Huichun Li, Yue Teng, Zhenghu Zu, Jingning Chen

• Scientific question. • Accurate reconstruction of early-stage cross-regional epidemic dynamics is critically hindered by reporting delays, heterogeneous surveillance systems, and limited case observations. How to efficiently calibrate reporting delays and infer key epidemiological parameters in large-scale spatial metapopulation models remains an …

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Optimization of Infectious Disease Intervention Measures Based on Reinforcement Learning -- Empirical analysis based on UK COVID-19 epidemic data

Baida Zhang, Y. Chen, Huichun Li, Zhenghu Zu

Globally, the outbreaks of infectious diseases have exerted an extremely profound and severe influence on health security and the economy. During the critical phases of epidemics, devising effective intervention measures poses a significant challenge to both the academic and practical arenas. There …

Ecological carrying capacity evaluation from the perspective of social-ecological coupling in the Qilian Mountains, northwest China

Qinqin Du, Qingzheng Wang, Qingyu Guan, Yunfan Sun et autres

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Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism

Shih‐Yen Lo, Meng‐Jiun Lai, Chee-Hing Yang, Huichun Li

Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (RNR), and SAM and HD domain-containing protein 1 (SAMHD1), among others. …

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Quantifying the potential of cascade outbreaks via early infected nodes using network percolation

Xin Li, Huichun Li, Xue Zhang, Chengli Zhao et autres

In many fields, accurate prediction of cascade outbreaks during their early stages of propagation is of paramount importance. Based on percolation theory, we propose a global propagation probability algorithm that effectively estimates the probability of information spreading from source nodes to the …

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Theoretical carrying capacity of grasslands and early warning for maintaining forage-livestock balance in the Qilian Mountains, northwest China

Qinqin Du, Yunfan Sun, Qingyu Guan, Qingzheng Wang et autres

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Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication

Chee-Hing Yang, Cheng-Hao Wu, Shih‐Yen Lo, Ahai-Chang Lua et autres

Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis. Large DNA viruses, such as herpesviruses and poxviruses, could benefit their …

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Attention-based hierarchical random graph model for structural inference of real-world networks

Huichun Li, Xue Zhang, Chengli Zhao, Zhengming Wang

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Detecting early-warning signals for social emergencies by temporal network sociomarkers

Huichun Li, Xin Li, Xue Zhang, Chengli Zhao et autres

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Strategies of Influenza A Virus to Ensure the Translation of Viral mRNAs

Huichun Li, Chee-Hing Yang, Shih‐Yen Lo

Viruses are obligatorily intracellular pathogens. To generate progeny virus particles, influenza A viruses (IAVs) have to divert the cellular machinery to ensure sufficient translation of viral mRNAs. To this end, several strategies have been exploited by IAVs, such as host gene shutoff, …

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