Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication
Chee-Hing Yang, Cheng-Hao Wu, Shih‐Yen Lo, Ahai-Chang Lua et autres
Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis. Large DNA viruses, such as herpesviruses and poxviruses, could benefit their …
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Pathogens