Giovanna Giuseppina Altobelli

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanna Giuseppina Altobelli, Soraya Scuderi, Gianfilippo Coppola, Jun Hyan Park et autres

Human induced pluripotent stem cells (hiPSCs) are emerging as a useful tool for modelling in vitro early brain development and neurological disorders. Molecular mechanisms and cell interactions that regulate the neurodevelopment at early stages remain unclear because of human brain’s complexity and …

Pik3ip1 mediates thyroid hormone-dependent regulation of the PI3K/Akt/mTOR axis in muscle atrophy

Annarita Nappi, Serena Sagliocchi, Federica Restolfer, Caterina Miro et autres

Skeletal muscle atrophy is driven by an imbalance between anabolic and catabolic signaling pathways, often involving suppression of the PI3K/Akt/mTOR axis. Thyroid Hormones (THs) are key endocrine regulators of skeletal muscle metabolism and adaptation, exerting context-dependent effects that promote either muscle atrophy …

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Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

Jessica Gambardella, Antonella Fiordelisi, Federica Andrea Cerasuolo, Antonietta Buonaiuto et autres

Abstract Increased literature support the pathogenetic role of dysfunctional energetic metabolism in the setup and progression of organ damage and failure. Genetic diseases often offer the possibility to investigate pathogenetic mechanisms. In particular, excessive cardiac damage is the most frequent cause of …

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Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells

Jelena Dimitrov, Maurizio Maddalena, Cristina Terlizzi, Giovanna Giuseppina Altobelli et autres

Introduction: Neutrophil extracellular traps (NETs) are complex structures released by activated neutrophils that may modulate different steps of the metastatic cascade. The aim of our study was to investigate how NETs can modulate the adhesion properties of cancer cells and whether cell …

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Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment

Maria Rosaria Ruocco, Armando Gisonna, Vittoria Acampora, Anna Grazia D'Agostino et autres

Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of cancer cells and an ever-changing tumor microenvironment (TME). The TME includes, among other non-cancer cell types, immune cells influencing the immune context of cancer tissues. In particular, the cross talk …

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Macrophages participate in doxorubicin-induced cardiac damage

Federica Andrea Cerasuolo, Jessica Gambardella, Gaetano Santulli, Antonella Fiordelisi et autres

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Macrophages release miRNAs in response to Doxorubicin with a potential role in indirect cardiac damage

Antonietta Buonaiuto, Jessica Gambardella, Gaetano Santulli, Antonella Fiordelisi et autres

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ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

Cristina Terlizzi, Viviana De Rosa, Francesca Iommelli, Antonio Pezone et autres

BACKGROUND: ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress response and metabolic diversion of glucose through the pentose phosphate pathway. …

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Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines

Jessica Gambardella, Gaetano Santulli, Antonella Fiordelisi, Federica Andrea Cerasuolo et autres

BACKGROUND: The functional contribution of non-myocyte cardiac cells, such as inflammatory cells, in the setup of heart failure in response to doxorubicin (Dox) is recently becoming of growing interest. OBJECTIVES: The study aims to evaluate the role of macrophages in cardiac damage …

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β3AR-dependent BDNF generation limits chronic post-ischemic heart failure

Seungho Jun, Alessandro Cannavò, Giuseppe Rengo, Federica Marzano et autres

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β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure

Alessandro Cannavò, Seungho Jun, Giuseppe Rengo, Federica Marzano et autres

BACKGROUND: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic receptor stimulation enhances local BDNF expression. It is unclear if this occurs in a pathophysiological relevant manner in the heart, especially …

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Use of Natural Agents and Agrifood Wastes for the Treatment of Skin Photoaging

Melania Parisi, Mariavittoria Verrillo, Maria Antonietta Luciano, Giuseppina Caiazzo et autres

Photoaging is the premature aging of the skin caused by repeated exposure to ultraviolet (UV) rays. The harmful effects of UV rays-from the sun or from artificial sources-alter normal skin structures and cause visible damage, especially in the most exposed areas. Fighting …

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