Reut Guy

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Proposed Therapy in a Rat Model of Cerebral Small Vessel Disease

Reut Guy, Shay Herman, Hadar Benyamini, Tali Ben‐Zur et autres

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been employed in the past decade as therapeutic agents in various diseases, including central nervous system (CNS) disorders. We currently aimed to use MSC-EVs as potential treatment for cerebral small vessel disease (CSVD), a complex …

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Extracellular vesicles over adeno-associated viruses: Advantages and limitations as drug delivery platforms in precision medicine

Nataly Yom-Tov, Reut Guy, Daniel Offen

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A Novel Rodent Model of Hypertensive Cerebral Small Vessel Disease with White Matter Hyperintensities and Peripheral Oxidative Stress

Reut Guy, Rotem Volkman, Ella Wilczynski, Chana Yagil et autres

Cerebral small vessel disease (CSVD) is the second most common cause of stroke and a major contributor to dementia. Manifestations of CSVD include cerebral microbleeds, intracerebral hemorrhages (ICH), lacunar infarcts, white matter hyperintensities (WMH) and enlarged perivascular spaces. Chronic hypertensive models have …

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Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

Reut Guy, Daniel Offen

Neurodegenerative disease refers to any pathological condition in which there is a progressive decline in neuronal function resulting from brain atrophy. Despite the immense efforts invested over recent decades in developing treatments for neurodegenerative diseases, effective therapy for these conditions is still …

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Ectopic human muscle progenitor cells expression of neurotrophic factors improves recovery in a mouse model of sciatic nerve injury

Reut Guy, Frida Grynspan, Tali Ben‐Zur, Avraham Panski et autres

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Human Muscle Progenitor Cells Overexpressing Neurotrophic Factors Improve Neuronal Regeneration in a Sciatic Nerve Injury Mouse Model

Reut Guy, Frida Grynspan, Tali Ben‐Zur, Avraham Panski et autres

The peripheral nervous system has an intrinsic ability to regenerate after injury. However, this process is slow, incomplete, and often accompanied by disturbing motor and sensory consequences. Sciatic nerve injury (SNI), which is the most common model for studying peripheral nerve injury, …

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Human muscle progenitor cells ectopically expressing neurotrophic factors enhance intrinsic neuronal regeneration in a sciatic nerve injury mouse model

Daniel Offen, Reut Guy, Tali Ben‐Zur, Felix Benninger et autres

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