Tali Ben‐Zur

Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies

Amanda Qarawani, Efrat Naaman, Rony Ben‐Zvi Elimelech, Michal Harel et autres

Amyloid β (Aβ) has emerged as a pathophysiological driver in age-related macular degeneration (AMD), emphasizing its significance in the aetiology of this prevalent sight-threatening condition. The multifaceted nature of AMD pathophysiology, presumably involving diverse retinal cascades, corresponds with the complexity of Aβ-induced …

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Mesenchymal Stem Cell-Derived Extracellular Vesicles as Proposed Therapy in a Rat Model of Cerebral Small Vessel Disease

Reut Guy, Shay Herman, Hadar Benyamini, Tali Ben‐Zur et autres

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been employed in the past decade as therapeutic agents in various diseases, including central nervous system (CNS) disorders. We currently aimed to use MSC-EVs as potential treatment for cerebral small vessel disease (CSVD), a complex …

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Increased RNA editing in maternal immune activation model of neurodevelopmental disease

Hadas Tsivion-Visbord, Eli Kopel, Ariel Feiglin, Tamar Sofer et autres

The etiology of major neurodevelopmental disorders such as schizophrenia and autism is unclear, with evidence supporting a combination of genetic factors and environmental insults, including viral infection during pregnancy. Here we utilized a mouse model of maternal immune activation (MIA) with the …

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Chemotherapy Controls Metastasis Through Stimulatory Effects on GRP78 and Its Transcription Factor CREB3L1

Annat Raiter, Julia Lipovetsky, Lucila Hyman, Shany Mugami et autres

To achieve a cure for metastatic breast cancer, further understanding of molecular drivers of the metastatic cascade is essential. Currently, chemotherapy regimens include doxorubicin and paclitaxel which act in part by inducing the unfolded protein response (UPR). The master regulator of the …

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Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer’s Disease

Rotem Volkman, Tali Ben‐Zur, A. Kahana, Ben Zion Garty et autres

Myeloperoxidase (MPO) is an enzyme expressed mostly by neutrophils and is a primary mediator of neutrophils oxidative stress response. While a profound body of evidence associates neutrophil-derived MPO in the pathogenesis of Alzheimer's disease (AD), this role has not been assessed in …

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Mscs-derived evs as potential treatment in a phencyclidine model of schizophrenia

H. Tsivion, Nisim Perets, Tali Ben‐Zur, L. Bikovsky et autres

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ApoE4 allele specific knockout using a synthetic Cas9 variant as a potential gene therapy approach for Alzheimer's disease

Roy Rabinowitz, A. Kadair, Tali Ben‐Zur, Daniel M. Michaelson et autres

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Myeloperoxidase ablation ameliorates behavioral and inflammatory-related features in the 5XFAD mouse model of alzheimer's disease (AD)

Rotem Volkman, Tali Ben‐Zur, A. Kahana, Ben Zion Garty et autres

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Ectopic human muscle progenitor cells expression of neurotrophic factors improves recovery in a mouse model of sciatic nerve injury

Reut Guy, Frida Grynspan, Tali Ben‐Zur, Avraham Panski et autres

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Increase in autophagy and amyloid beta uptake in apoe expressing astrocytes after calpain knock down by CRISPR-Cas9

Daniel Offen, A. Anidjar, Shira Simonovitch, Tali Ben‐Zur et autres

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The Role of MAPK's Signaling in Mediating ApoE4-Driven Pathology In Vivo

Shiran Salomon‐Zimri, Amit Koren, Ariel Angel, Tali Ben‐Zur et autres

BACKGROUND: Alzheimer's Disease (AD) is associated with impairments in key brain Mitogen- Activated Protein Kinase (MAPK) signaling cascades including the p38, c-Jun N-terminal kinase (JNK), ERK and Akt pathways. Apolipoprotein E4 (ApoE4) is the most prevalent genetic risk factor of AD. OBJECTIVES: …

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Human Muscle Progenitor Cells Overexpressing Neurotrophic Factors Improve Neuronal Regeneration in a Sciatic Nerve Injury Mouse Model

Reut Guy, Frida Grynspan, Tali Ben‐Zur, Avraham Panski et autres

The peripheral nervous system has an intrinsic ability to regenerate after injury. However, this process is slow, incomplete, and often accompanied by disturbing motor and sensory consequences. Sciatic nerve injury (SNI), which is the most common model for studying peripheral nerve injury, …

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