Roman Záhorec

Perioperative Management of Patients Taking GLP-1 Receptor Agonists. A Mini-Review

Lucia Hradská Smilková, Roman Záhorec

In July 2025, the British Journal of Anaesthesia published recommendations for the perioperative management of patients using GLP-1 receptor agonists. The authors of this multidisciplinary consensus are SPAQI, the Society for Perioperative Assessment and Quality Improvement. GLP-1 receptor agonists (GLP-1RA) are medications …

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Complete Blood Count as a Tool for Screening Cancer, Indices, Scores and Predictive Models

Roman Záhorec, Vitězoslav Marek, Katarina TARABOVA

Cancer-related systemic inflammation is a hallmark of cancer. Investigation of complete blood count may provide sufficient objective laboratory data to measure the intensity of cancer-associated inflammation. Routinely used hematological and biochemical laboratory parameters have the potential to evaluate the immune–inflammatory response to …

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Correction: The Association Between Preoperative Single High-Dose Vitamin D3 Supplementation and Acute Respiratory Distress Syndrome Incidence in Patients After Oesophageal Resection for Carcinoma: a Randomised, Placebo-Controlled Trial

Katarina TARABOVA, Miroslav Janík, Iveta Waczulı́ková, Peter Juhos et autres

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Neutrophil-to-lymphocyte ratio reflects inflammatory phenotypes of alcohol-associated hepatitis: differences between mild and severe disease

Daniela Žilinčanová, Svetlana Adamcova Selcanova, Daniela Havaj, Karolina Sulejova et autres

Úvod a ciele: Alkoholová choroba pečene (ALD) predstavuje jednu z hlavných príčin pokročilého chronického ochorenia pečene na celom svete a je predominantnou etiológiou cirhózy v mnohých európskych regiónoch. Alkoholom asociovaná hepatitída (AH) predstavuje zápalovú manifestáciu ALD a zahàňa široké spektrum závažnosti ochorenia …

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The Association Between Preoperative Single High-Dose Vitamin D3 Supplementation and Acute Respiratory Distress Syndrome Incidence In Patients After Oesophageal Resection For Carcinoma: A Randomised, Placebo-Controlled Trial

Katarina TARABOVA, Miroslav Janík, Iveta WACZULIKOVA, Peter Juhos et autres

This randomised controlled trial (RCT) evaluated whether preoperative supplementation with 300,000 IU of cholecalciferol could reduce the risk of acute respiratory distress syndrome (ARDS) in patients undergoing oesophagectomy for carcinoma. Oesophagectomy carries substantial postoperative morbidity, particularly respiratory complications, with ARDS as the …

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Prognostic Value of Neutrophil-to-Lymphocyte Ratio Across Barcelona Clinic Liver Cancer Stages in Hepatocellular Carcinoma: A Multicenter Retrospective Analysis

Dominik Šafčák, Sylvia Dražilová, Jakub Gazda, Svetlana Adamcova Selcanova et autres

Abstract Introduction Hepatocellular carcinoma (HCC) is the 6th most common malignancy worldwide with variable prognostic outcomes. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential prognostic marker, but its applicability across Barcelona Clinic Liver Cancer (BCLC) stages remains unclear. This study aims …

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Neutrophil-to-lymphocyte ratio in acute decompensation of advanced chronic liver disease and acute-on-chronic liver failure: prognostic significance by etiology

Daniela Žilinčanová, Svetlana Adamcová-Selčanová, Daniel J. Havaj, Karolína K. Šulejová et autres

Aim of the study: The neutrophil-to-lymphocyte ratio (NLR) is a simple and widely available indicator of the degree and balance of the systemic inflammatory response in critically ill patients and has been shown to predict outcomes across multiple liver syndromes, including alcohol-associated …

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Consensus statement for managing patients with ARDS in low-resource settings: a Delphi study

Peđja Kovačević, Jesús Villar, Boris Tomić, Fabio Silvio Taccone et autres

Background: Despite decades of research and advances in critical care, mortality of the Acute Respiratory Distress Syndrome (ARDS) remains high, ranging from 30 to 45% in high-income countries and markedly higher in low-resource settings (LRS), where management guidelines implementation is constrained. An …

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Prognostic Value of Neutrophil-to-Lymphocyte Ratio Across BCLC Stages in Hepatocellular Carcinoma: A Multicenter Retrospective Analysis

Dominik Šafčák, Sylvia Dražilová, Jakub Gazda, Svetlana Adamcová-Selčanová et autres

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Diagnosis of sepsis: which clinical and laboratory biomarkers are useful?

Miroslav Průcha, Roman Záhorec

The quest for a definitive diagnostic tool for sepsis has spanned decades, yet it remains elusive. The diagnostic workup of sepsis is inherently complex, involving dozens of biochemical, hematologic, and immunologic parameters, alongside complex microbiological diagnostics. Over the past decade, the integration …

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About a New Palpation Sign in the Diagnosis of Acute Appendicitis in Children and Women of Childbearing Age

Víťezslav Marek, Štefan Durdík, Roman Záhorec

Acute appendicitis (AA) is defined as nonspecific bacterial inflammation of the appendix vermiformis and is the most common acute abdominal condition requiring surgical intervention. The clinical picture of atypical forms of AA (children, women of childbearing age) is often insidious with its …

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Sepsis as a Challenge for Personalized Medicine

Roman Záhorec, Miroslav Průcha

Sepsis is a clinical syndrome of systemic inflammation induced by infection, now defined as life-threatening organ dysfunction caused by a dysregulated immune response to infection [...].

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