Jingqian Liu

Improving All-Atom Molecular Dynamics Models for Quantitative Prediction of Nanopore Blockade Current

Jingqian Liu, Crystal Rodriguez, Min Chen, Aleksei Aksimentiev

All-atom molecular dynamics has become an indispensable tool in development of nanopore sensors of biological information. In a typical nanopore experiment, measurements of ionic current flowing through a nanopore report on the chemical structure of biomolecules that pass through the nanopore. Such …

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Development of novel quinoline derivatives as selective HDAC6 inhibitors exhibiting multiple anticancer effects

Jie Peng, Qianlong Zhao, Changan Yu, Wenjia Liu et autres

cn (code pays fourni par la source)

Development of Novel Quinoline Derivatives as Selective HDAC6 Inhibitors Exhibiting Multiple Anticancer Effects

Jie Peng, Qianlong Zhao, Changan Yu, Wenjia Liu et autres

Full-length protein classification via cysteine fingerprinting in solid-state nanopores

Neeraj Soni, Zohar Rosenstock, Navneet Chandra Verma, K. Siddharth et autres

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BPS2025 - Reparameterization of DNA-protein interaction improves the description of nanopore DNA sequencing

Jingqian Liu, Min Chen, Aleksei Aksimentiev

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HDAC8 as a target in drug discovery: Function, structure and design

Qianlong Zhao, Hongyan Liu, Jie Peng, Haoqian Niu et autres

cn (code pays fourni par la source)

HDAC6 mediates tumorigenesis during mitosis and the development of targeted deactivating agents

Jie Peng, Hongyan Liu, Yujing Liu, Jingqian Liu et autres

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Discovery of Novel 4-(Naphthalen-2-Yl)Tetrahydro-2h-Pyran Derivatives as Hdac Inhibitors for Cancer Treatment

Yujing Liu, Peng Jie, Jingqian Liu, Wenjia Liu et autres

Molecular Determinants of Current Blockade Produced by Peptide Transport Through a Nanopore

Jingqian Liu, Aleksei Aksimentiev

The nanopore sensing method holds the promise of delivering a single molecule technology for identification of biological proteins, direct detection of post-translational modifications, and perhaps de novo determination of a protein's amino acid sequence. The key quantity measured in such nanopore sensing …

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Recent development of selective inhibitors targeting the HDAC6 as anti-cancer drugs: Structure, function and design

Jie Peng, Fei Xie, Pengxia Qin, Yujing Liu et autres

cn (code pays fourni par la source)

Expanding the Molecular Alphabet of DNA-Based Data Storage Systems with Neural Network Nanopore Readout Processing

S. Kasra Tabatabaei, Bach Pham, Chao Pan, Jingqian Liu et autres

DNA is a promising next-generation data storage medium, but challenges remain with synthesis costs and recording latency. Here, we describe a prototype of a DNA data storage system that uses an extended molecular alphabet combining natural and chemically modified nucleotides. Our results …

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Assessing the feasibility of protein sequencing using biological nanopores

Jingqian Liu, Kumar Sarthak, Behzad Mehrafrooz, Aleksei Aksimentiev

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