Jie Peng

Association between urinary cadmium exposure and metabolic syndrome and the mediating role of thyroid dysfunction: NHANES 2007 to 2012

Jie Peng, Sijiong Wang, Ye Liu, Lichao ZHU et autres

This study aims to examine the association between urinary cadmium (U-Cd) exposure and metabolic syndrome (MetS) in U.S. adults and evaluate whether thyroid function (TSH/T4) mediates this relationship. We analyzed National Health and Nutrition Examination Survey 2007-2012 data (n = 4869; age …

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Causal association between artificial sweeteners and risk of 15 tumors: A 2-way 2-sample Mendelian randomization analysis

Haiyuan Yang, Ye Liu, Jie Peng, Yiheng Zhang et autres

The aim of this study was to apply a 2-sample Mendelian randomization approach, uncovering the causal link between artificial sweetener (AS) intake in cereals, coffee and tea and cancer. For this purpose, the research team obtained and utilized comprehensive data from published …

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Iron homeostasis: effects of different levels of protein iron on placental iron handling in sows

Deyuan Wu, Jiawei Nie, Liudan Liu, Lili Wang et autres

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A foundation language model to decipher diverse regulation of RNAs

Hanwen Zhou, Yue Hu, Yulong Zheng, Jiefu Li et autres

BACKGROUND: RNA metabolism is tightly regulated by cis-elements and trans-acting factors. Most information guiding such regulation is encoded in RNA sequences. Deciphering the regulatory rules is critical for RNA biology and therapeutics; however, the prediction of diverse regulation from RNA sequences remains …

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Effectiveness and safety of pirfenidone for radiation-induced lung injury in non-small cell lung cancer: a retrospective pilot study

Xuzhen Liu, Fangyang Lu, Lili Zhao, Dan Zou et autres

BACKGROUND: Radiotherapy (RT) remains a cornerstone in the treatment of thoracic malignancies; however, approximately one-third of patients with non-small cell lung cancer (NSCLC) develop Grade ≥ 2 radiation-induced lung injury (RILI). Despite its clinical significance, no pharmacologic standard of care has been …

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The Role of Radiotherapy in Unresectable Primary Pulmonary Sarcoma: A Multicenter Study

A. Liu, Xianli Yin, Juan Wen, Jie Peng et autres

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Computed tomography-based quantification of intra-tumoral heterogeneity for predicting treatment response to concurrent chemoradiotherapy in non-small cell lung cancer: a multicenter retrospective study

Benlan Li, Zhongjun Huang, Yongxiang Hu, Bo Du et autres

Background: Concurrent chemoradiotherapy (CCRT) constitutes a cornerstone of treatment for non-small cell lung cancer (NSCLC). However, NSCLC's intrinsic heterogeneity yields variable therapeutic responses. Noninvasive, quantitative assessment of intra-tumoral heterogeneity (ITH) may improve prediction of treatment efficacy. This study sought to derive ITH …

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986P Phase I study of NovoTTF-100L(P) in combination with chemotherapy in patients with predominant hepatic metastatic colorectal cancer

Siqing Fu, Harold Nathan Tan, Jordi A. Rodon, Ecaterina E Ileana Dumbrava et autres

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Comment on “Global research trend of graphene application in breast cancer: a bibliometric analysis”

Ye Liu, Huifeng Yang, Jie Peng, Yating Zhao

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A novel radiomics model combining GTVp, GTVnd, and clinical data for chemoradiotherapy response prediction in patients with advanced NSCLC

Ya Li, Min Zhang, Yong Hu, Dan Zou et autres

Background: Numerous radiomic models have been developed to predict treatment outcomes in patients with NSCLC receiving chemotherapy and radiation therapy. However, computed tomography (CT) radiomic models that integrate the Gross Tumour Volume of the primary lesion (GTVp), the Gross Tumour Volume of …

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Cladribine and medium-dose cytarabine intensified busulfan plus cyclophosphamide conditioning regimen for adults high-risk B-cell acute lymphoblastic leukemia

Tingting Cheng, Jie Peng, Yi Liu, Shuanghui Yang et autres

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective salvage strategy for B-cell acute lymphoblastic leukemia (B-ALL). In this study, we explored the efficacy and safety of cladribine and medium-dose cytarabine intensified busulfan plus cyclophosphamide conditioning regimen (CBAC) for high-risk B-ALL …

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Pretreatment CT-Based Machine Learning Radiomics Model Predicts Response in Inoperable Stage III NSCLC Treated with Concurrent Radiochemotherapy Plus PD-1 Inhibitors

Ya Li, Min Zhang, Yong Hu, Bo Du et autres

ObjectiveTo develop and validate a CT-based radiomics model for predicting sequential immunotherapy response after concurrent radiochemotherapy (CCRT) in patients with unresectable stage III non-small cell lung cancer (NSCLC).MethodsThe study retrospectively included 71 patients who received sequential immunotherapy after concurrent chemoradiotherapy (CCRT) between …

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