David W. Gjertson

Pretransplant circulating cTfh17 and donor-reactive T follicular helper responses distinguish liver transplant recipients who develop ischemia-reperfusion injury and donor-specific antibody

Adil Bhat, Rebecca A. Sosa, Allyson Q. Terry, Ying Zheng et autres

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Multi-omic profiling of kidney transplant recipients highlights IL-2 as a potential, pre-viremic signature of cytomegalovirus infection

H. Pickering, Richard S. Ahn, J. Arakawa-Hoyt, Suphamai Bunnapradist et autres

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Elevated NK and T cell-associated cytokines in plasma are associated with serological response to influenza vaccination

Harry C. Pickering, Michael A. Carlock, Monica Cappelletti, David W. Gjertson et autres

Introduction: Numerous pre-vaccination factors are known to be associated with differential responses to influenza vaccination, including age, prior infection, vaccination history, immune cell frequencies, and transcriptomic profiles. However, plasma chemokines and cytokines are relatively unexplored. Given that older individuals have generally higher …

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Pre-Viremic, Multi-Omic Immune Signatures of Cytomegalovirus Infection in Kidney Transplant Recipients

H. Pickering, Richard S. Ahn, J. Arakawa-Hoyt, Alexander Hoffmann et autres

Purpose: Cytomegalovirus (CMV) causes mostly asymptomatic but lifelong infection. However, CMV infection in immunocompromised kidney transplant recipients (KTx) significantly increases morbidity and mortality, and decreases graft survival. Despite antiviral prophylaxis, CMV viremia occurs in up to 50% of high risk CMV seropositive …

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Elevated Levels of Circulating Oxidized Mitochondrial DNA Contribute to the Development of Ischemia Reperfusion Injury Following Liver Transplantation

Sushant Bhat, Ajmal Rashid Bhat, Rebecca A. Sosa, Bita V. Naini et autres

Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation triggers inflammation through the release of damage-associated molecular patterns (DAMPs) from necrotic and apoptotic cells. We have observed that post-reperfusion plasma (liver flush, LF) activates the TLR9 pathway, suggesting the presence of an unidentified DAMP …

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UCLA International MICA Exchange – An update

A.F. Locke, David W. Gjertson, Elaine F. Reed, Z. Qiuheng

Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs

Jackson L. Chin, Zhixin Cyrillus Tan, Liana C. Chan, Felicia Ruffin et autres

(MRSA) bacteremia is a common and life-threatening infection that imposes up to 30% mortality even when appropriate therapy is used. Despite in vitro efficacy determined by minimum inhibitory concentration breakpoints, antibiotics often fail to resolve these infections in vivo, resulting in persistent …

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Myeloid spatial and transcriptional molecular signature of ischemia-reperfusion injury in human liver transplantation

Rebecca A. Sosa, Richard S. Ahn, Fang Li, Allyson Q. Terry et autres

BACKGROUND: Ischemia-reperfusion injury (IRI) is a significant clinical concern in liver transplantation, with a key influence on short-term and long-term allograft and patient survival. Myeloid cells trigger and sustain tissue inflammation and damage associated with IRI, but the mechanisms regulating these activities …

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Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis

Rebecca A. Sosa, Allyson Q. Terry, Takahiro Ito, Bita V. Naini et autres

Background: Nonalcoholic steatohepatitis (NASH) is a severe immune-mediated stage of nonalcoholic fatty liver disease that is rapidly becoming the most common etiology requiring liver transplantation (LT), with Hispanics bearing a disproportionate burden. This study aimed to uncover the underlying immune mechanisms of …

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O22 Effector memory and TH17 CD4+ T cells are increased in liver transplant patients experiencing ischemia-reperfusion injury

Ajaz Ahmad Bhat, S Sen, Allyson Q. Terry, Rebecca A. Sosa et autres

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P617 Alloimmune endotypes and related outcomes in human liver transplantation

Rebecca A. Sosa, Allyson Q. Terry, Yuebang Yin, Bita V. Naini et autres

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Disulfide-HMGB1 signals through TLR4 and TLR9 to induce inflammatory macrophages capable of innate-adaptive crosstalk in human liver transplantation

Allyson Q. Terry, Hidenobu Kojima, Rebecca A. Sosa, Fady M. Kaldas et autres

Ischemia-reperfusion injury (IRI) during orthotopic liver transplantation (OLT) contributes to graft rejection and poor clinical outcomes. The disulfide form of high mobility group box 1 (diS-HMGB1), an intracellular protein released during OLT-IRI, induces pro-inflammatory macrophages. How diS-HMGB1 differentiates human monocytes into macrophages …

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