Sushant Bhat

A G57 (BJ/94-like) H9N2 avian influenza virus exhibits enhanced replication and tissue dissemination in chickens compared with a G1-B virus

Sushant Bhat, Jean-Rémy Sadeyen, Jiayun Yang, Klaudia Chrząstek et autres

Graphical abstract Analysis of H9N2 lineages shows G57 virus replicates, spreads and transmits more efficiently than G1‑B, driven by their gene constellations, enhanced neuraminidase activity, sulphated avian receptor binding and acid‑stable haemagglutinin.

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Differential outcomes of viral co-infections with high pathogenicity avian influenza A(H5N6) and SARS-CoV-2 in mammalian in vitro systems

Samuel A. S. Richardson, Nitish Boodhoo, Sushant Bhat, Joanna Wells et autres

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Genetic characterization of equine arteritis virus associated with outbreaks in the UK, 2019

Sushant Bhat, Jean‐Pierre Frossard, Bhudipa Choudhury, Falko Steinbach

Equine arteritis virus (EAV) is the causative agent of equine viral arteritis, a notifiable respiratory and reproductive disease of equids that causes significant losses to the equine industry. This study presents a comprehensive analysis of two EAV outbreaks in the UK in …

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Highly Pathogenic Avian Influenza (HPAI) H5N1 in Raw Pet Foods and Milk: A Growing Threat to both Companion Animals and Human Health, and Potential Raw Pet Food Industry Liability

Janak Dhakal, Sushant Bhat, Joe James, Richard Yaw Otwey et autres

The increasing popularity of raw meat-based diets (RMBDs) and raw milk feeding in companion animals presents a growing concern for zoonotic disease transmission. Recent evidence has demonstrated that these products can serve as vehicles for highly pathogenic avian influenza (HPAI) H5N1, an …

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Ischemia-reperfusion injury triggers post-transplant cytokine dysregulation and donor-specific antibody formation, driving poor liver graft outcomes in liver transplantation

Adil Bhat, Rebecca A. Sosa, Sushant Bhat, Bita V. Naini et autres

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Ischemia-Reperfusion Injury Drives Cytokine Dysregulation, Early Monocyte Activation, and Poor Outcomes in Liver Transplantation

Arshad Bhat, Rebecca A. Sosa, Sushant Bhat, Bita V. Naini et autres

Purpose: Ischemia-reperfusion injury (IRI) remains a critical barrier drives graft dysfunction and rejection risk in orthotopic liver transplantation (OLT). However, the interplay between post-transplant cytokine dynamics, monocyte differentiation, and alloreactive T cell expansion remains poorly understood. We investigated these immune signatures to …

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Elevated Levels of Circulating Oxidized Mitochondrial DNA Contribute to the Development of Ischemia Reperfusion Injury Following Liver Transplantation

Sushant Bhat, Ajmal R. Bhat, Rebecca A. Sosa, Bita V. Naini et autres

Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation triggers inflammation through the release of damage-associated molecular patterns (DAMPs) from necrotic and apoptotic cells. We have observed that post-reperfusion plasma (liver flush, LF) activates the TLR9 pathway, suggesting the presence of an unidentified DAMP …

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The G57 genotype of the BJ/94-like H9N2 lineage exhibits increased replication and virulence in chickens compared to the G1 Middle East Group B lineage

Sushant Bhat, Jean-Rémy Sadeyen, Jiayun Yang, Klaudia Chrząstek et autres

Abstract Avian influenza H9N2 viruses cause significant economic losses to the poultry industry and pose a public health risk due to their potential to reassort with other avian influenza viruses, generating strains with zoonotic and pandemic potential. Two major H9N2 lineages dominate …

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Best friends or biggest enemies: Differential outcomes of viral co-infections with highly pathogenic avian influenza A(H5N6) and SARS-CoV-2 in mammalian in vitro systems

Samuel Richardson, Nitish Boodhoo, Sushant Bhat, Joanna Wells et autres

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Ischemia reperfusion injury drives post-operative monocyte differentiation and alloreactivity in orthotopic liver transplant patients

Adil Bhat, Rebecca A. Sosa, Sushant Bhat, Ying Zheng et autres

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Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo

Dagmara Bialy, Samuel Richardson, Klaudia Chrząstek, Sushant Bhat et autres

The possible emergence of drug-resistant avian flu raises concerns over the limited effectiveness of currently approved antivirals (neuraminidase inhibitors - NAIs) in the hypothetical event of a zoonotic spillover. Our study demonstrated that the recombinant avian A(H6N1) viruses showed reduced inhibition (RI) …

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Investigation of H9N2 avian influenza immune escape mutant that lacks haemagglutination activity

Thusitha K. Karunarathna, Jean-Rémy Sadeyen, Sushant Bhat, Pengxiang Chang et autres

ABSTRACT H9N2 avian influenza viruses pose a global threat to animal and human health. While vaccination is essential for mitigating disease impact, these viruses evolve to evade vaccine immunity through changes in the haemagglutinin (HA) glycoprotein. In this study, we identified immune …

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