Ashwini Shete

Role of IL-12 Levels in Diagnosing Tuberculosis Among People Living with HIV Receiving Antiretroviral Therapy

Ashwini Shete, Manisha Ghate, Sandip Patil, Pallavi Shidhaye et autres

Human immunodeficiency virus and tuberculosis (HIV/TB) coinfection remains a major global health challenge. Immune dysregulation in HIV complicates TB diagnosis. The type of immune response mounted in tuberculosis is a key determinant in deciding the outcome of the infection. Hence, estimating immune …

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Efficacy and safety of VPM1002 and Immuvac in preventing tuberculosis: phase 3 randomised clinical trial (PreVenTB trial)

Manjula Singh, Sindhu Joshi, Vikram Vohra, Rohit Sarin et autres

Abstract Objective To evaluate the safety and efficacy of VPM1002 and Immuvac in reducing the incidence of microbiologically confirmed tuberculosis (TB; pulmonary TB and extrapulmonary TB), development of latent TB infection, and immunogenicity. Design Phase 3 randomised clinical trial (PreVenTB trial). Setting …

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Effect of Timing and Duration of ART on the Composition of HIV Reservoirs: Implications for HIV Cure Strategies

Sukeshani Salwe, Ashwini Shete

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Peer Review Report For: Quantification of 25-hydroxyvitamin D3 in dried blood spots as compared to plasma among Indian adults [version 2; peer review: 1 approved, 2 approved with reservations]

Ashwini Shete, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule et autres

Background Vitamin D may play an important role in later-life physical and cognitive health. Vitamin D status is standardly assessed in serum and plasma; however, collection, transport, and storage costs make large epidemiologic studies challenging. We assessed the agreement of 25-hydroxyvitamin D …

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HbA1c alone might not reliably indicate India's diabetes prevalence – Authors' reply

T V Sekher, David Flood, Peifeng Hu, Mohammed K. Ali et autres

Lovely Gupta and colleagues question the use of HbA1c in the Longitudinal Aging Study in India (LASI). We wish to make three points. First, we did not “concede … that HbA1c-only diagnosis is flawed”, and we disagree with the letter's suggestion that …

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Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV

Sathi Koar, Rohini Bingewar, Jyoti Sawant, Pallavi Shidhaye et autres

Background Oxidative stress contributes to DNA damage, further leading to cellular senescence. HIV infection increases oxidative stress and interferes in DNA damage response. Hence, a study was conducted to assess the extent of DNA damage by evaluating global methylation, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and …

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Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older

T. V. Sekher, David Flood, Hunter Green, Peifeng Hu et autres

Background India is a country of 1·4 billion people that contributes to much of the global diabetes burden. Updated evidence on the state of the diabetes epidemic among middle-aged and older adults is imperative given that the risk of diabetes increases with …

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Peer Review Report For: Quantification of 25-hydroxyvitamin D3 in dried blood spots as compared to plasma among Indian adults [version 2; peer review: 1 approved, 1 approved with reservations]

Ashwini Shete, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule et autres

Background Vitamin D may play an important role in later-life physical and cognitive health. Vitamin D status is standardly assessed in serum and plasma; however, collection, transport, and storage costs make large epidemiologic studies challenging. We assessed the agreement of 25-hydroxyvitamin D …

in, us (code pays fourni par la source)

Quantification of 25-hydroxyvitamin D3 in dried blood spots as compared to plasma among Indian adults

Ashwini Shete, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule et autres

Background Vitamin D may play an important role in later-life physical and cognitive health. Vitamin D status is standardly assessed in serum and plasma; however, collection, transport, and storage costs make large epidemiologic studies challenging. We assessed the agreement of 25-hydroxyvitamin D …

in, us (code pays fourni par la source)

Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy

Ashwini Shete, Pallavi Shidhaye, Amrita Rao, Nikita Bhawari et autres

BACKGROUND: People living with HIV (PLHIV) demonstrate accelerated aging and immunosenescence in spite of immune-restoration following long-term antiretroviral treatment (ART). Low level inflammation leading to inflammaging plays an important role in mediating premature immunosenescence. Ongoing viral replication, antiretrovirals and subclinical infections with …

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Peer Review Report For: Quantification of 25-hydroxyvitamin D3 in dried blood spots as compared to plasma among Indian adults [version 1; peer review: 2 approved with reservations]

Ashwini Shete, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule et autres

Background Vitamin D may play an important role in later-life physical and cognitive health. Vitamin D status is standardly assessed in serum and plasma; however, collection, transport, and storage costs make large epidemiologic studies challenging. We assessed the agreement of 25-hydroxyvitamin D3 …

in, us (code pays fourni par la source)

Peer Review Report For: Quantification of 25-hydroxyvitamin D3 in dried blood spots as compared to plasma among Indian adults [version 1; peer review: 2 approved with reservations]

Ashwini Shete, Jyoti Sawant, Rajani Bagul, Ujjwala Ghule et autres

Background Vitamin D may play an important role in later-life physical and cognitive health. Vitamin D status is standardly assessed in serum and plasma; however, collection, transport, and storage costs make large epidemiologic studies challenging. We assessed the agreement of 25-hydroxyvitamin D3 …

in, us (code pays fourni par la source)