Reversal of perturbed DNA damage response and HIV latency by a histone methyltransferase inhibitor in virally suppressed individuals living with HIV
Sathi Koar, Rohini Bingewar, Jyoti Sawant, Pallavi Shidhaye et autres
Background Oxidative stress contributes to DNA damage, further leading to cellular senescence. HIV infection increases oxidative stress and interferes in DNA damage response. Hence, a study was conducted to assess the extent of DNA damage by evaluating global methylation, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and …
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Frontiers in Aging