Jun Hashiguchi

Dipeptidyl peptidase-4 inhibitors reduce the incidence of first cardiovascular events in Japanese diabetic patients

Hirofumi Soejima, Hisao Ogawa, Takeshi Morimoto, Sadanori Okada et autres

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Kidney function deterioration is dependent on blood pressure levels: 11.2 year follow-up in diabetic patients

Hirofumi Soejima, Hisao Ogawa, Takeshi Morimoto, Sadanori Okada et autres

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Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial

Chisa Matsumoto, Hisao Ogawa, Yoshihiko Saito, Sadanori Okada et autres

OBJECTIVE To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women. RESEARCH DESIGN AND METHODS This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin …

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Effect of Aspirin on Cancer Chemoprevention in Japanese Patients With Type 2 Diabetes: 10-Year Observational Follow-up of a Randomized Controlled Trial

Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma et autres

OBJECTIVE This study analyzed the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes. RESEARCH DESIGN AND METHODS This study was a posttrial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial. Participants in the …

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Adipokines and the Prediction of the Accumulation of Cardiovascular Risk Factors or the Presence of Metabolic Syndrome in Elementary School Children

Masao Yoshinaga, Koji Sameshima, Yuji Tanaka, Akihiro Wada et autres

BACKGROUND: Information is limited about how adipokines predict the accumulation of cardiovascular (CV) risk factors or the presence of metabolic syndrome (MS) in children. METHODS AND RESULTS: The subjects were 321 children (200 boys and 121 girls; 109 normal and 212 obese) …

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Emergence of Cardiovascular Risk Factors From Mild Obesity in Japanese Elementary School Children

Masao Yoshinaga, Koji Sameshima, Michihisa Jougasaki, Hideki Yoshikawa et autres

Clustering of individual cardiovascular risk factors, such as central obesity, insulin resistance, hypertension, and dyslipidemia, together known as metabolic syndrome, is largely confined to obese populations in both children and adults (1,2). The underlying pathophysiology of metabolic syndrome is thought to be …

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Metabolic Syndrome in Overweight and Obese Japanese Children

Masao Yoshinaga, Satoru Tanaka, Atsushi Shimago, Koji Sameshima et autres

OBJECTIVE: To determine the prevalence of and sex differences related to the metabolic syndrome among obese and overweight elementary school children. RESEARCH METHODS AND PROCEDURES: Subjects were 471 overweight or obese Japanese children. Children meeting at least three of the following five …

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Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese

Hajime Nawata, Senji Shirasawa, Naoki Nakashima, Eiichi Araki et autres

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Rapid increase in the prevalence of obesity in elementary school children

Masao Yoshinaga, Atsushi Shimago, Chihaya Koriyama, Yuichi Nomura et autres

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Prevention of mildly overweight children from development of more overweight condition

Masao Yoshinaga, Koji Sameshima, Koichiro Miyata, Jun Hashiguchi et autres

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Who is becoming overweight during the elementary school years?

Masao Yoshinaga, Chihaya Koriyama, Atsushi Shimago, Kohei Miyata et autres

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What kinds of conformations are induced on poly(L-lysine) by phospholipids/non-ionic surfactant aggregates?

Kohsuke Fukushima, Jun Hashiguchi, Ryosuke Shimozawa