Hajime Nawata

Arterial stiffness, high fasting glucose, and fatty liver as risk factors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study

Hajime Nawata, Li Ou, Xu Zhang, Qinglan Song et autres

The prevalence of obesity is increasing rapidly worldwide, particularly in Asia. Visceral obesity, characterized by intra-abdominal fat accumulation, is a precursor to metabolic syndrome, encompassing hyperglycemia, dyslipidemia, and hypertension, which elevate the risk of atherosclerosis and cardiovascular disease. A visceral fat area …

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Arterial stiffness, high fasting glucose, and fatty liver as predictors for visceral obesity in middle-aged Chinese individuals: a cross-sectional study

Hajime Nawata, Li Ou, Xu Zhang, Qinglan Song et autres

Abstract Background The prevalence of obesity is increasing rapidly worldwide, including in Asia. Visceral obesity, i.e., intra-abdominal fat accumulation, precedes the development of obesity-related metabolic syndrome, based on the cluster of hyperglycemia, dyslipidemia, and hypertension, leading to atherosclerosis and cardiovascular disease. Visceral …

Celebration of 100th anniversary of the Japan Endocrine Society

Hajime Nawata

I heartily celebrate the 100 th anniversary of the Japan Endocrine Society to express my respect about this milestone being reached.I celebrated the 80 th anniversary of the Japan Endocrine Society as its 16 th president at Hamarikyu Asahi Hall in Tokyo …

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Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes–a cross-sectional study

Ikumi Yanagita, Yuya Fujihara, Chikayo Iwaya, Yuichi Kitajima et autres

BACKGROUND: Frailty is broadly characterized by vulnerability and decline in physical, mental and social activities and is more common in elderly patients with type 2 diabetes mellitus (T2DM). Frailty is closely associated with nutrition, muscle strength, inflammation, and hormones etc. In hormones, …

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Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes–a cross-sectional study

Ikumi Yanagita, Yuya Fujihara, Chikayo Iwaya, Yuichi Kitajima et autres

Abstract Background: Frailty is broadly characterized by vulnerability and decline in physical, mental and social activities and is more common in elderly patients with type 2 diabetes mellitus (T2DM). Frailty is closely associated with nutrition, muscle strength, inflammation, and hormones etc. In …

Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes – a cross-sectional study

Toshihiko Yanase, Ikumi Yanagita, Yuya Fujihara, Chikayo Iwaya et autres

Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes – a cross-sectional study

Toshihiko Yanase, Ikumi Yanagita, Yuya Fujihara, Chikayo Iwaya et autres

Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes: possible mechanistic role of dehydroepiandrosterone sulfate – a cross-sectional study

Toshihiko Yanase, Ikumi Yanagita, Yuya Fujihara, Chikayo Iwaya et autres

A nationwide survey of adrenal incidentalomas in Japan: the first report of clinical and epidemiological features

Takamasa Ichijo, Hajime Ueshiba, Hajime Nawata, Toshihiko Yanase

The aim of this study was to reveal clear epidemiologic and clinical characteristics of incidentally discovered adrenal masses, termed adrenal incidentalomas (AIs), and to establish appropriate managemental and therapeutic regimens in Japan. This study had been originally carried out as a project …

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SUN-026 Selective Androgen Receptor Modulator S42 Has Anabolic and Anti-Catabolic Effects on Cultured Myotubes

Yoshimi Muta, Tomoko Tanaka, Yuriko Hamaguchi, Nobuya Hamanoue et autres

Introduction: In an effort to develop a selective androgen receptor modulator (SARM) with beneficial activity in energy homeostasis, we previously screened 119 steroid analogs for the ability to induce uncoupling protein-1 (UCP-1) mRNA without increasing prostate-specific antigen promoter activity in human prostate …

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A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients

Ikumi Yanagita, Yuya Fujihara, Yuichi Kitajima, Misuzu Tajima et autres

CONTEXT: Elderly patients with type 2 diabetes mellitus (T2DM) have a high prevalence of frailty and/or sarcopenia. Sarcopenia is thought to be related to discordant secretions of the adrenal hormones cortisol and dehydroepiandrosterone (DHEA), as well as the sulfate ester of DHEA …

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Selective androgen receptor modulator, S42 has anabolic and anti-catabolic effects on cultured myotubes

Yoshimi Muta, Tomoko Tanaka, Yuriko Hamaguchi, Nobuya Hamanoue et autres

We previously identified a novel selective androgen receptor modulator, S42, that does not stimulate prostate growth but has a beneficial effect on lipid metabolism. S42 also increased muscle weight of the levator ani in orchiectomized Sprague–Dawley rats. These findings prompted us to …

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