Jessica L. Gifford

Result Interpretation in Skewed Populations—Are Common Reference Intervals Inadequate?

Dennis J. Orton, Jessica L. Gifford, Gregory A. Kline

BACKGROUND: Reference intervals (RIs) are defined as the central 95th percentile of a healthy population, and many biomarkers exhibit a skewed result distribution. Here we demonstrate interpretive variations for results from a gaussian vs skewed distribution RI. METHODS: De-identified patient data were …

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Best practice recommendations for laboratory analysis and reporting of cerebrospinal fluid oligoclonal banding and associated tests for multiple sclerosis (MS): a consensus report from the harmonized CSF analysis for MS investigation (hCAMI) subcommittee of the Canadian society of clinical chemists (CSCC)

Victoria Higgins, Michelle Parker, Basma Ahmed, Vipin Bhayana et autres

Cerebrospinal fluid (CSF) oligoclonal banding (OCB) analysis is an important component in the diagnosis of multiple sclerosis (MS). In the 2024 McDonald Criteria for MS diagnosis, CSF-specific OCB can support MS diagnosis, including in those with relapsing or progressive presentations, as well …

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Effect of microcollection tube fill volume on common acute care tests

Fangze Cai, Isolde Seiden‐Long, Allison A. Venner, Heather Anne Paul et autres

BACKGROUND: Microcollection tubes are frequently used in pediatric phlebotomy. We performed a pilot study to determine what clinical biochemistry and hematology tests can be reported on different microcollection tube fill volumes. METHODS: Blood was collected from 11 volunteers into Becton Dickinson (BD) …

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B-102 Harmonizing cerebrospinal fluid analysis for multiple sclerosis investigation: An update from the hCAMI subcommittee of the Canadian Society of Clinical Chemists (CSCC)

Victoria Higgins, Daniel R. Beriault, Michelle B. Parker, Vipin Bhayana et autres

Abstract Background Laboratory tests are increasingly important for diagnosing multiple sclerosis (MS). Cerebrospinal fluid (CSF) laboratory testing, including detection of CSF oligoclonal bands (OCB), aids in the diagnosis of MS but significant variability in reporting practices across Canadian clinical laboratories has been …

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A-215 Slightly cloudy urine: a benign finding or a call for microscopy?

Michael Stuart Reid, Fangze Cai, Sally Ezra, Dustin T. Proctor et autres

Abstract Background Urinalysis testing for community patients in Alberta, Canada is mainly conducted at two central laboratories using automated analyzers. These analyzers employ reflex rules to trigger automated microscopy when certain criteria are met. Although microscopy is automated, many images still require …

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Underfilled tubes revisited: What blood tests can be reported on short draws?

Lawrence de Koning, Sally Ezra, Fangze Cai, Isolde Seiden‐Long et autres

OBJECTIVE: Underfilled blood tubes (short draws) are often collected from children or those with poor venous access. In a pilot study, we investigated which tests among a large acute care panel could be reported on short draws. METHODS: Blood was drawn in …

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Oligoclonal banding analysis: assessing plasma use and time interval requirements for paired CSF and blood

Lily Olayinka, Yu Chen, Karina Rodríguez-Capote, Jessica L. Gifford et autres

Article Oligoclonal banding analysis: assessing plasma use and time interval requirements for paired CSF and blood was published on June 26, 2025 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 0, issue 0).

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Multidisciplinary approach to redefining thyroid hormone reference intervals with big data analysis

Cody Wayne Lewis, Joshua E. Raizman, Victoria Higgins, Jessica L. Gifford et autres

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B-127 The Effect of Hemolysis on Potassium Measurement in a Community Setting: The Marching Error

Francisco Y. Cai, Hong Anh Luu, Stuart Logan, M. S. Reid et autres

Abstract Background Potassium is one of the most sensitive analytes to in-vitro hemolysis. To detect this error, modern clinical chemistry analyzers calculate the hemolysis index (HI) to estimate the degree of specimen hemolysis. Recently, Roche Diagnostics lowered the acceptable potassium HI limit …

Increased Lp(a) Workload Volumes Reflect Uptake of the 2021 Canadian Cardiovascular Society Guidelines for Management of Dyslipidemia

Dennis J. Orton, Jessica L. Gifford, Joshua E. Raizman, Glen J. Pearson et autres

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Validating the NIH LDL-C equation for provincial implementation in Alberta

Victoria Higgins, Lucia García, Jessica L. Gifford, Nataliya Volodko et autres

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B-062 A Self-Imposed Gray Area? Analysis of Anti-Tissue Transglutaminase and Anti-Endomysial Antibody Discordance in a Celiac Disease Screening Serology Testing Algorithm

Saul Ezra, Danny Orton, Jessica L. Gifford

Abstract Background Celiac disease (CD) is an autoimmune enteropathy affecting around 1% of the population. While occasionally asymptomatic, the disease can present in a variety of ways and can be triggered by dietary gluten at any age. CD serology, including anti-tissue transglutaminase …

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