Cody Wayne Lewis

B-295 Lower Tacrolimus Trough Levels as a Predictor of Antibody-Mediated Rejection in Kidney Transplant Patients

Cody Wayne Lewis, Ahmed Mostafa, Fang Ping Wu, Jing Liu

Abstract Background Successful kidney transplantation requires compatibility between the organ recipient and donor in Human Leukocyte Antigen (HLA) matching. If the donor and recipient are not compatible, the recipient’s immune system may attack the transplanted kidney, leading to antibody-mediated rejection (AMR) or …

ca (code pays fourni par la source)

A-117 An intriguing case of the green plasma

Wei Xu, Fang‐Xiang Wu, Cody Wayne Lewis

Abstract Background A green-colored plasma sample sent to the lab for chemistry testing raises concerns about potential interferences. After consultation with the clinical care team, the source of the green coloration is determined to be methylene blue. Methylene blue is commonly used …

ca (code pays fourni par la source)

A-180 Counting CAP deficiency Caused by Clerical errors: a regional study

Peter Xu, Fang‐Xiang Wu, Cody Wayne Lewis

Abstract Background Proficiency testing (PT) is a critical component of quality assurance and a laboratory accreditation requirement. PT ensures that laboratory results are comparable to those of peers using the same instruments and methods. Failures may indicate inaccurate patient results, requiring formal …

ca (code pays fourni par la source)

A-393 Evaluating Discrepancies in Transcutaneous Bilirubin Measurements: The Impact of Skin Tone and Device Precision on Neonatal Jaundice Screening

Cody Wayne Lewis, Sukhbir Pal Kaur

Abstract Background Dräger Jaundice Meter JM-105 is a transcutaneous bilirubin (TcB) meter utilized to screen neonates for jaundice in Saskatoon, Saskatchewan Canada. Elevated TcB readings are followed up with core laboratory testing of total serum bilirubin (TSB), and patients with high TSB …

ca (code pays fourni par la source)

Performance of the Siemens’ thyroid stimulating immunoglobulin assay in the diagnosis of hyperthyroidism: Prospective cohort study

Gregory A. Kline, Dustin T. Proctor, Nadia Moledina, Heather Anne Paul et autres

ca (code pays fourni par la source)

Multidisciplinary approach to redefining thyroid hormone reference intervals with big data analysis

Cody Wayne Lewis, Joshua E. Raizman, Victoria Higgins, Jessica L. Gifford et autres

ca (code pays fourni par la source)

Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors

Sargun Sokhi, Cody Wayne Lewis, Amirali B. Bukhari, J. A. Hadfield et autres

Cell cycle checkpoint kinases serve as important therapeutic targets for various cancers. When they are inhibited by small molecules, checkpoint abrogation can induce cell death or further sensitize cancer cells to other genotoxic therapies. Particularly aberrant Cdk1 activation at the G2/M checkpoint …

ca (code pays fourni par la source)

Supplementary Data from Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

Cody Wayne Lewis, Amirali B. Bukhari, Edric J. Xiao, Wonshik Choi et autres

suppl figures 1-6. SF1: Myt1 knockdown sensitizes breast cells to Adavosertib; SF2: Wee1 knockdown mimics Adavosertib treatment; SF3: Adavosertib does not inhibit Myt1 activity; SF4: Adavosertib resistant cells do not prematurely enter mitosis; SF5: Adavosertib induced mitotic exit delays occur in cells …

Data from Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

Cody Wayne Lewis, Amirali B. Bukhari, Edric J. Xiao, Wonshik Choi et autres

Abstract Adavosertib (also known as AZD1775 or MK1775) is a small-molecule inhibitor of the protein kinase Wee1, with single-agent activity in multiple solid tumors, including sarcoma, glioblastoma, and head and neck cancer. Adavosertib also shows promising results in combination with genotoxic agents …

Supplementary Data from Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

Cody Wayne Lewis, Amirali B. Bukhari, Edric J. Xiao, Wonshik Choi et autres

figure legend for Suppl Figure 1-6; supple tables 1-3

Supplementary Data from Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

Cody Wayne Lewis, Amirali B. Bukhari, Edric J. Xiao, Wonshik Choi et autres

figure legend for Suppl Figure 1-6; supple tables 1-3

Supplementary Data from Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

Cody Wayne Lewis, Amirali B. Bukhari, Edric J. Xiao, Wonshik Choi et autres

suppl figures 1-6. SF1: Myt1 knockdown sensitizes breast cells to Adavosertib; SF2: Wee1 knockdown mimics Adavosertib treatment; SF3: Adavosertib does not inhibit Myt1 activity; SF4: Adavosertib resistant cells do not prematurely enter mitosis; SF5: Adavosertib induced mitotic exit delays occur in cells …