Alexander J F Thurston

Macrotroponin Complexes and Risk of Cardiovascular Events

Marie de Bakker, Alexander J F Thurston, Ola Hammarsten, Mareta Khachatryan et autres

BACKGROUND: Cardiac troponin is increasingly used for cardiovascular risk prediction. While abnormal values often reflect subclinical cardiovascular disease, they can be raised due to interference, where antibodies influence the assay or clearance of troponin from the circulation by forming macrotroponin complexes. The …

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Evaluation of risk stratification at presentation using the Alinity high-sensitivity cardiac troponin I assay

Ziwen Li, Takeshi Fujisawa, Øyvind Skadberg, Paul Fineran et autres

Abstract Background High-sensitivity cardiac troponin (hs-cTn) assays enable safe early discharge of patients at very low risk for myocardial infarction. We previously developed a single-sample rule-out pathway using the ARCHITECT hs-cTnI assay to risk stratify patients with suspected acute coronary syndrome. In …

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Immature neutrophils sound the alarm in acute myocardial infarction

Alexander J F Thurston, Nicholas L. Mills

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Trends in the Assessment, Treatment and Outcomes of Patients with Suspected Acute Coronary Syndrome

Franz Gruber, Alexander J F Thurston, Sara Hatam, Ryan Wereski et autres

Abstract Background Suspected acute coronary syndrome is a frequent Emergency Department (ED) presentation, requiring safe and efficient assessment. We interrogated long-term trends in whole population care for these patients using a new multi-centre regional registry. Methods The DataLoch Heart Disease Registry links …

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Single-Sample Rule-Out Pathway for Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay

Ziwen Li, Takeshi Fujisawa, Øyvind Skadberg, Alexander J F Thurston et autres

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Sixth Generation High-Sensitivity Cardiac Troponin T: Will a Better Assay Make a Better Biomarker?

Amber Pollock, Alexander J F Thurston, Andrew R Chapman, Nicholas L Mills

The development of the first cardiac troponin T assay (cTnT) in 1987 was a major breakthrough in the clinical diagnosis of myocardial infarction (1). The combination of high specificity for myocardial injury and increasing sensitivity has transformed the diagnostic pathway for patients …

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Clinical Decisions and Outcomes After Switching High-Sensitivity Cardiac Troponin Assays in Suspected ACS

Jasper Boeddinghaus, Ziwen Li, Anda Bularga, Caelan Taggart et autres

Importance: High-sensitivity cardiac troponin T and I assays are considered equivalent for the diagnosis of myocardial infarction. However, the impact of transitioning from an assay measuring cardiac troponin I to one measuring cardiac troponin T on patient care and clinical outcomes is …

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Cardiovascular Risk Across Myocardial Injury and Infarction Categories Using the Universal Definition

Jasper Boeddinghaus, Pedro López‐Ayala, Alexander J F Thurston, Kuan Ken Lee et autres

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Change in cardiac troponin T to differentiate acute from chronic myocardial injury in the Emergency Department

Bertil Lindahl, Alexander J F Thurston, Yong Yong Tew, Michael McDermott et autres

INTRODUCTION: Persistently elevated cardiac troponin (cTn) values are observed in many patients with suspected acute coronary syndrome (ACS) in the absence of myocardial infarction and may reflect underlying cardiac disease. Chronic myocardial injury is defined where cTn values are elevated and vary …

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Cardiovascular and non-cardiovascular mortality at 5 years in patients with type 1 and type 2 myocardial infarction

Caelan Taggart, Alexander J F Thurston, Deepak Harry, Yong Yong Tew et autres

Type 2 myocardial infarction (MI) occurs due to myocardial oxygen supply or demand imbalance, often during another acute illness, in the absence of coronary atherothrombosis. In patients aged over 70 years, it is responsible for over one in three in-hospital MI events, …

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Implications of a new clinical classification of acute myocardial infarction

Alexander J F Thurston, Jasper Boeddinghaus, Andrew R. Chapman, Bertil Lindahl et autres

Alexander J F Thurston, Jasper Boeddinghaus, Andrew R Chapman, Bertil Lindahl, Nicholas L Mills; Implications of a new clinical classification of acute myo

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Implications of a new clinical classification of acute myocardial infarction

Jasper Boeddinghaus, Caelan Taggart, Ryan Wereski, Michael McDermott et autres

AIMS: The diagnostic criteria for Type 2 myocardial infarction identify a heterogeneous group of patients with variable outcomes and no clear treatment implications. We aimed to determine the implications of a new clinical classification for myocardial infarction with more objective diagnostic criteria …

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