Anna Valeriánová

Sex differences in management and outcomes after out-of-hospital cardiac arrest with angiographically confirmed obstructive coronary artery disease

Klaudia Svitekova, Daniel Rob, Eliska Mockova, Petra Kavalkova et autres

Neurofilament light chain for assessment of brain injury in four porcine cardiac arrest models

Olof Persson, Attila Frigyesi, Anna Valeriánová, Mikuláš Mlček et autres

Background Anoxic brain injury is the leading cause of death following successful resuscitation after out-of-hospital cardiac arrest. No experimental neuroprotective therapy has translated into clinical benefit. Collaborative efforts to harmonize methods may be essential for translational success. Neurofilament light chain (NfL) is …

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Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Marion Moseby‐Knappe, Helena Levin, Susann Ullén, Henrik Zetterberg et autres

BACKGROUND: Prognostication of recovery in patients who are unconscious following cardiac arrest can be guided by concentrations of brain injury biomarkers in the blood. The optimal biomarker and cutoff concentrations for the prediction of outcome remain unknown. In this study, we aimed …

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Hypothermia after Cardiac Arrest in Large Animals (HACA-LA): a randomized controlled experimental study

Olof Persson, Anna Valeriánová, Leoš Tejkl, Jan Bělohlávek et autres

BACKGROUND: Induced hypothermia after cardiac arrest is neuroprotective in several animal models of cardiac arrest, but few high-quality studies have been conducted in larger animals. Recent clinical trials have questioned the beneficial effects of post-ischemic hypothermia. This study investigated whether immediate cooling …

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Lower cholesterol level on admission predicts poor outcome after prolonged cardiac arrest

Jan Malík, Anna Valeriánová, Tomáš Janota, Jana Šmalcová et autres

Higher cholesterol level is a risk factor of coronary artery disease, the major cause of sudden cardiac death (SCD). However, smaller studies observed worse outcomes in SCD patients having lower total and LDL-cholesterol levels. Therefore, the prognostic role of cholesterol itself in …

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Reasons for death in patients receiving ECPR for refractory out-of-hospital cardiac arrest

Klaudia Farkasovska, Daniel Rob, Marie Dacev, Petra Kaválková et autres

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First Real-Time Imaging of Acute Effects of Arteriovenous Fistula on Regional Distribution of Pulmonary Perfusion in a Novel Porcine Model

João Batista Borges, Anna Valeriánová, Leoš Tejkl, Jan Malík et autres

The effects of a large arteriovenous fistula (AVF) on pulmonary perfusion remains to be elucidated. We aimed to study, for the first time, the real-time acute effects of a large AVF on regional distribution of pulmonary perfusion in a novel porcine model. …

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Clinical characteristics, management, and predictors of mortality: results from the national prospective cardiogenic shock registry (CZECH-SHOCK)

Michal Pazderník, Petr Ošťádal, Jiří Seiner, Jan Pudil et autres

AIMS: Only limited epidemiological data exist from national or international prospective multicentre registries covering the whole spectrum of cardiogenic shock (CS) aetiologies. METHODS AND RESULTS: A national prospective multicentre observational study, CZECH-SHOCK, was conducted in 15 main tertiary care centres in Czechia …

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Right ventricular-pulmonary arterial coupling and pulmonary hypertension in hemodialysis: insights into structural cardiac changes and clinical implications

Kristína Burýšková Salajová, Jan Malík, Lucie Kaiserova, Zuzana Hladinová et autres

Objectives This cross-sectional analysis from the CZecking Heart Failure in patients with advanced Chronic Kidney Disease trial (ISRCTN18275480) examined pulmonary hypertension and right ventricular-pulmonary arterial coupling in patients on chronic hemodialysis. The aims of this analysis were: 1. To analyze relations between …

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514 Neurofilament Light Chain levels in a randomized porcine cardiac arrest hypothermia model

Olof Persson, Anna Valeriánová, Jan Bělohlávek, Mikuláš Mlček et autres

350 Comparison of Plasma Neurofilament Light Chain Levels in Porcine Cardiac Arrest Models

Olof Persson, Mikuláš Mlček, Anna Valeriánová, Renaud Tissier et autres

Higher blood glucose within the first 72 hours after prolonged cardiac arrest predict poor prognosis: a post-hoc analysis of Prague OHCA trial

Jan Malík, Anna Valeriánová, Tomáš Janota, Kristína Burýšková Salajová et autres

Abstract Background and purpose Both low and higher glucose levels and their tight control were associated with worse prognosis of critically ill patients. We performed a post-hoc analysis of treated Prague OHCA trial population of patients subjected to extracorporeal cardiopulmonary resuscitation (ECPR) …

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