Tomoki Iguchi

Structure determination of cardenolide glycosides from the bulbs of Ornithogalum ponticum and their cytotoxicity against human lung cancer cell lines

Tomoki Iguchi, Mika Ueno, Tamami Shimazaki, Yoshihiro Mimaki

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Apoptosis- and ferroptosis-inducing activity of triptolide in SBC-3 human small-cell lung cancer cells

Tomoki Iguchi, Yoshihiro Mimaki

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Novel steroidal glycosides from the underground parts of Agapanthus africanus and their cytotoxicity against human cancer cell lines

Tomoki Iguchi, N Takahashi, Anju Nagamine, Akihiro Nagata et autres

Approximately 25% of all new anticancer agents approved by the Food and Drug Administration between January 1981 and September 2019 were derived from natural products and their derivatives, suggesting that natural products continue to play a crucial role in the development of …

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Thirty-five steroidal glycosides from Ornithogalum thyrsoides bulbs and their cytotoxicity against human leukemia cells and human small-cell lung cancer cells

Tamami Shimazaki, Tomoki Iguchi, N Takahashi, Yukako Sano et autres

The authors have previously reported several cholestane- and spirostan-type steroidal glycosides from Ornithogalum thyrsoides [ 1 ] [ 2 ] [ 3 ] [ 4 ]. Since conventional TLC analysis of the extract of O. thyrsoides bulbs suggested the presence of unprecedented …

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Steroidal components of the whole plants of Helleborus niger L. and their cytotoxicity

Yuka Yoshizawa, Akihito Yokosuka, Tomoki Iguchi, Y Mimaki

The genus Helleborus (Ranunculaceae) includes about 20 species, most of which are cultivated for ornamental purposes. Among them, Helleborus niger L., commonly known as Christmas rose, is native to the alpine regions of southern and central Europe. Our previous phytochemical studies on …

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Agapanthussaponin A from the Underground Parts of Agapanthus africanus Induces Apoptosis and Ferroptosis in Human Small-Cell Lung Cancer Cells

Tomoki Iguchi, Tamami Shimazaki, Yoshihiro Mimaki

To explore the potential seed compounds from natural products as anticancer agents against small-cell lung cancer (SCLC), the underground parts of Agapanthus africanus, a plant commonly used for ornamental purposes, were investigated. Three spirostan-type steroidal glycosides (1–3) were isolated and identified by …

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Apoptosis-inducing activity of a steroidal glycoside from Allium chinense G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress

Tamami Shimazaki, Tomoki Iguchi, Aki Kanda, Yoshihiro Mimaki

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Structural determination of two undescribed triterpenoids from Punica granatum L. peels

Tomoki Iguchi, Tamami Shimazaki, Yoshihiro Mimaki

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Steroidal constituents in the whole plants of Helleborus niger and their cytotoxic activity in vitro

Yuka Yoshizawa, Akihito Yokosuka, Mina Inomata, Tomoki Iguchi et autres

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Steroidal glycosides from Ornithogalum thyrsoides bulbs and their cytotoxicity toward HL-60 human promyelocytic leukemia cells and SBC-3 human small-cell lung cancer cells

Tamami Shimazaki, Tomoki Iguchi, Naoki Takahashi, Yukako Sano et autres

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Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products

Takashi Shii, Tomoki Iguchi, Minpei Kuroda, Tamami Shimazaki et autres

Abstract Aim Currently, no information regarding the sennosides A and B content is provided on bofutsushosan extract products for ethical use. In this study, sennosides A and B in bofutsushosan extract products from eight different pharmaceutical companies and those in bofutsushosan decoction …

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Six unprecedented steroidal glycosides from Allium atropurpureum bulbs and their cytotoxicities against SBC-3 human small-cell lung cancer cells

Tamami Shimazaki, Tomoki Iguchi, Aki Kanda, Kie Yamamoto et autres

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